DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and Slc6a3

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_036826.1	Gene:	Slc6a3 / 24898	RGDID:	3715	Length:	619	Species:	Rattus norvegicus

Alignment Length:	610	Identity:	317/610 - (51%)
Similarity:	416/610 - (68%)	Gaps:	44/610 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ISKSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGI 71
            |:..:||..        :.||||||.|:|||||||||||||||||||||||||||||||||||.:
  Rat    48 INPPQTPVE--------AQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLL 104

  Fly    72 MLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFF 136
            .:|:.|:|||||||||||.||:||...| ::.|:.||:|:.|:||:|||.|:|||||||:|.:||
  Rat   105 FMVIAGMPLFYMELALGQFNREGAAGVW-KICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFF 168

  Fly   137 ASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSA 201
            :|||..|||..|||.||:|||....:.|:|                ..|..|:|:  |:
  Rat   169 SSFTMDLPWIHCNNTWNSPNCSDAHASNSS----------------DGLGLNDTF--GT------ 209

  Fly   202 VGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVW 266
                    :.|:|||.|.:|.|::|.||.|||..:|.:..||::|.::.|||||||:.|||||||
  Rat   210 --------TPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVW 266

  Fly   267 FTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAY 331
            .||..||.||..||:||:||||:..||:.||:.:|..:.:|.||:||||||.||||.|||||:|:
  Rat   267 ITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAF 331

  Fly   332 ASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAA 396
            :||||:.||.|:||::|:.|||.|||.:|||:||.|||||....|.|.||||:||||:|::||.|
  Rat   332 SSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEA 396

  Fly   397 IATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLA 461
            |||:|.|:.||.:||:||||||:||:.||.|::||.|.|||..:.|:||||..|:....|::.|.
  Rat   397 IATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLF 461

  Fly   462 SCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFV 526
            ..|.||.|.|.|||.:|||.|||..|..|||.|:|.||..:||:||:.|.|..|..||::||:.|
  Rat   462 CVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLV 526

  Fly   527 APIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFT 591
            :|.|||::.|..::.:.|..|..|::|.|||||||.||.||:.|:|..|.:|..|.|||.|::..
  Rat   527 SPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLA 591

  Fly   592 ILTTPWRDQQSMAMVLNGVTTEVTV 616
            ...||.:|.|   :|..|...:.|:
  Rat   592 YAITPEKDHQ---LVDRGEVRQFTL 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	307/569 (54%)
Slc6a3	NP_036826.1	SLC6sbd_DAT1	60..613	CDD:212083	312/588 (53%)
Slc6a3	NP_036826.1	Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		15/28 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	664	1.000	Domainoid score	I144
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	675	1.000	Inparanoid score	I694
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		otm45897
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840