DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment DAT and Slc6a11

DIOPT Version :9

Sequence 1:NP_001261026.1 Gene:DAT / 36849 FlyBaseID:FBgn0034136 Length:644 Species:Drosophila melanogaster
Sequence 2:NP_766478.1 Gene:Slc6a11 / 243616 MGIID:95630 Length:627 Species:Mus musculus


Alignment Length:619 Identity:269/619 - (43%)
Similarity:372/619 - (60%) Gaps:57/619 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            ||..|:.||:|:|||.|..:.|.||||||||||||||||||:||.:..:..|||:|::|.||||.
Mouse    44 ERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQF 108

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            ..:|.||||.|:.|||:|||||..:|..:::.||.:|:||::.:....||..|||.:|.:.|||.
Mouse   109 TSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTE 173

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAAS---EYFN 217
            .|..|:..|.|      |||                            || ..|:|.|   |::.
Mouse   174 KCVEFQKLNFS------NYS----------------------------HV-SLQNATSPVMEFWE 203

  Fly   218 RYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIR 282
            |.:|.:  |:||..:|.::|::|||||..:.||||.:|||..::||||:.||.|||.:|||||||
Mouse   204 RRVLAI--SDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIR 266

  Fly   283 GLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALL 347
            |:||||:..||::||.|:.|.:...:|||||.||:|||.....|.|.|..|||.|:||.|:|.::
Mouse   267 GVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIM 331

  Fly   348 TSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFM 412
            ...:||.|||:|||.||||||:||:..||.|.:||..||||.|:.||.|:..||.|..||.:|||
Mouse   332 LCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFM 396

  Fly   413 MLLTLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLYFVVGLASCTQGGFYFFHLL 474
            ||:.|||||.|...|:::||:.|.:||:.|   .|||.:..|..:.:.:||...|:||.|.|.|.
Mouse   397 MLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLF 461

  Fly   475 DRYAA-GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYG 538
            |.||| |..:|....||.:.:.|:||:|||.::|.||||:.|....:.||:.|.|.....|.::.
Mouse   462 DSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFF 526

  Fly   539 LIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD--- 599
            |:.|:||.|.: |.||:|...:||.:|.||::.||.....||..|.|:|.::...||.|..|   
Mouse   527 LVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKM 591

  Fly   600 -----QQSMAMVLNGVTTEV----TVVRLTDTET 624
                 .....:.:|....:|    |:..:|:.||
Mouse   592 RGKLGASPRTVTVNDCEAKVKGDGTISAITEKET 625

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DATNP_001261026.1 SLC6sbd_SERT-like_u1 27..597 CDD:271405 260/577 (45%)
Slc6a11NP_766478.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..36
SLC6sbd_GAT3 44..585 CDD:212077 261/577 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0733
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53371
OrthoDB 1 1.010 - - D250396at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.830

Return to query results.
Submit another query.