Protein Alignment DAT and Slc6a11

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_766478.1
• Gene: Slc6a11 / 243616
• MGIID: 95630
• Length: 627
• Species: Mus musculus
• Alignment Length: 619
• Identity: 269/619 - (43%)
• Similarity: 372/619 - (60%)
• Gaps: 57/619 - (9%)

  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            ||..|:.||:|:|||.|..:.|.||||||||||||||||||:||.:..:..|||:|::|.||||.
Mouse    44 ERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQF 108

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            ..:|.||||.|:.|||:|||||..:|..:::.||.:|:||::.:....||..|||.:|.:.|||.
Mouse   109 TSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTE 173

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAAS---EYFN 217
            .|..|:..|.|      |||                            || ..|:|.|   |::.
Mouse   174 KCVEFQKLNFS------NYS----------------------------HV-SLQNATSPVMEFWE 203

  Fly   218 RYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIR 282
            |.:|.:  |:||..:|.::|::|||||..:.||||.:|||..::||||:.||.|||.:|||||||
Mouse   204 RRVLAI--SDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIR 266

  Fly   283 GLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALL 347
            |:||||:..||::||.|:.|.:...:|||||.||:|||.....|.|.|..|||.|:||.|:|.::
Mouse   267 GVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIM 331

  Fly   348 TSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFM 412
            ...:||.|||:|||.||||||:||:..||.|.:||..||||.|:.||.|:..||.|..||.:|||
Mouse   332 LCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFM 396

  Fly   413 MLLTLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLYFVVGLASCTQGGFYFFHLL 474
            ||:.|||||.|...|:::||:.|.:||:.|   .|||.:..|..:.:.:||...|:||.|.|.|.
Mouse   397 MLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIISYFLGLVMLTEGGMYIFQLF 461

  Fly   475 DRYAA-GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYG 538
            |.||| |..:|....||.:.:.|:||:|||.::|.||||:.|....:.||:.|.|.....|.::.
Mouse   462 DSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFF 526

  Fly   539 LIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD--- 599
            |:.|:||.|.: |.||:|...:||.:|.||::.||.....||..|.|:|.::...||.|..|
Mouse   527 LVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKM 591

  Fly   600 -----QQSMAMVLNGVTTEV----TVVRLTDTET 624
                 .....:.:|....:|    |:..:|:.||
Mouse   592 RGKLGASPRTVTVNDCEAKVKGDGTISAITEKET 625

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	260/577 (45%)
Slc6a11	NP_766478.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36
		SLC6sbd_GAT3	44..585	CDD:212077	261/577 (45%)