Protein Alignment DAT and Slc6a7

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_006525992.1
• Gene: Slc6a7 / 240332
• MGIID: 2147363
• Length: 684
• Species: Mus musculus
• Alignment Length: 635
• Identity: 278/635 - (43%)
• Similarity: 389/635 - (61%)
• Gaps: 45/635 - (7%)

  Fly     9 KSKTP----TPHDNDNNSI----SDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAF 65
            |..||    ||.|..:..:    :.:|..|:||:|||||.||:.|.|.|||||||..|.||||||
Mouse    58 KPITPDLLMTPSDQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGGGAF 122

  Fly    66 LVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAW 130
            ||||.:||.:.|||||::||:|||.:..|.:..| ::.|||||.|.|::||...|..|||:|||:
Mouse   123 LVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMIIAY 186

  Fly   131 SLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGS 195
            .|.:.|||.|::|||..|.|.|||..|.      ..|.|..||       |...|..:.|.
Mouse   187 VLFYLFASLTSNLPWEHCGNWWNTELCL------EHRGPKSGN-------GVLPLNLSSTV---- 234

  Fly   196 SLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGIST 260
                          |.:.||::||:|.:..|:||...|.|:|::.||||:.::|.:..:.||:.:
Mouse   235 --------------SPSEEYWSRYVLHIQGSQGIGRPGEIRWNLCLCLLLAWVIVFLCILKGVKS 285

  Fly   261 SGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGF 325
            |||||:|||.|||.:||:||:||:||||::.|||:||||.|..:..::||::||.|:|:|||.||
Mouse   286 SGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLGVGF 350

  Fly   326 GVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVF 390
            |.||.:||||.:|.|:|:|..:.:..|:.||.:|||.||||||||:..|||.::.||..||||.|
Mouse   351 GGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPGLAF 415

  Fly   391 VVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSL- 454
            ||||.|:..:|.|.||:.:||.|||||||||.|...|.|:||::||||...|.::...:||..:
Mouse   416 VVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLICVA 480

  Fly   455 YFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYW 519
            .:::||...|.||.|:..|||.|:|.:.::|.|....:||:.:||..||..||..|:||.||.|:
Mouse   481 MYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPGLYF 545

  Fly   520 QVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPG 584
            :.||.|::|..||.:.||.::.|:|..|..|.:|:||..||..:...|.:||||..:..:|...|
Mouse   546 RACWLFLSPATLLALLVYSIVKYQPSEYGSYRFPAWAELLGILMGLLSCLMIPAGMLVAVLREEG 610

  Fly   585 SLRQRFTILTTPWRDQQSMAMVLNGVTTEVTVVRLTDTETAKEPVDVXVR 634
            ||.:|....:.|..|   ....|....|.:.|..|..:::.| |:.| :|
Mouse   611 SLWERLQQASRPAMD---WGPSLEENRTGMYVATLAGSQSPK-PLMVHMR 656

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	262/570 (46%)
Slc6a7	XP_006525992.1	SLC5-6-like_sbd	84..628	CDD:444915	264/578 (46%)