Protein Alignment DAT and Slc6a1

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_848818.1
• Gene: Slc6a1 / 232333
• MGIID: 95627
• Length: 599
• Species: Mus musculus
• Alignment Length: 608
• Identity: 261/608 - (42%)
• Similarity: 378/608 - (62%)
• Gaps: 55/608 - (9%)

  Fly     5 GHISK--SKTPTPHDNDNNSI---------SDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCY 58
            |.||.  |:.|...|.....:         ..:|:||.|:.|||:|.:|:|:.|.|||||||||.
Mouse    11 GQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCG 75

  Fly    59 KNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFY 123
            ||||||||:||.:.|:..|:|||.:|.:|||:...|.:..| :|.|:|||:|.|..:::|:::.|
Mouse    76 KNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVW-KLAPMFKGVGLAAAVLSFWLNIY 139

  Fly   124 YNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYN 188
            |.|||:|::.:.:.|||.:|||..|:|.|||..|             ..|||          |.|
Mouse   140 YIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRC-------------FSNYS----------LVN 181

  Fly   189 ETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFS 253
            .|.|.                ||..|::.|.:.::  ::|:...|.|:|.:|:.|.|.:::.||.
Mouse   182 TTNMT----------------SAVVEFWERNMHQM--TDGLDKPGQIRWPLAITLAIAWVLVYFC 228

  Fly   254 LWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVF 318
            :|||:..:||||:|:|.:||.:|:||..||:||||:..||.:|:||||..:..:|||:|||||:|
Mouse   229 IWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIF 293

  Fly   319 FSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVAT 383
            ||.|.|.|.|:|..|||.:|||||:|:::...|||.||..|||||||::|:|||.....|.|||.
Mouse   294 FSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAA 358

  Fly   384 EGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRN-RELF 447
            .||||.|:.||.|:..:|.|..||::||.|||.||:||.|...|..||||.||:|::.|| ||||
Mouse   359 SGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELF 423

  Fly   448 VAGLFSLYFVVGLASCTQGGFYFFHLLDRY-AAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMI 511
            :|.:..:.:::||::.||||.|.|.|.|.| |:|.|:|..||||.:::||.||.|||.::|::|:
Mouse   424 IAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMV 488

  Fly   512 GFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAI 576
            |..|..:|::||.|..||.:..:.::..:...|||...||:|.|...:||.:|.||:|:||....
Mouse   489 GSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMA 553

  Fly   577 FKLLSTPGSLRQRFTILTTPWRD 599
            :..|:..|||:||..::..|..|
Mouse   554 YMFLTLKGSLKQRLQVMIQPSED 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	253/571 (44%)
Slc6a1	NP_848818.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		5/11 (45%)
		SLC6sbd_GAT1	2..599	CDD:212075	261/608 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	577..599		261/608 (43%)
		PDZ-binding	597..599

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820