Protein Alignment DAT and Slc6a18

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001035782.1
• Gene: Slc6a18 / 22598
• MGIID: 1336892
• Length: 615
• Species: Mus musculus
• Alignment Length: 657
• Identity: 230/657 - (35%)
• Similarity: 321/657 - (48%)
• Gaps: 134/657 - (20%)

  Fly    23 ISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELAL 87
            |.|||..|..|:.:|||.|||||.|.|:|||||||..:||||||:||.|.||..||||||:|||:
Mouse    13 IEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFEGIPLFYIELAI 77

  Fly    88 GQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIW 152
            ||..|:|:|..|..:.|...|:|.....::|.|..|||.::.|.|.||..||.:.|||::|
Mouse    78 GQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTVLLWVLWFFLNSFQHPLPWSTC---- 138

  Fly   153 NTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFN 217
                                                       .||.:..|.|:..||:.:..:.
Mouse   139 -------------------------------------------PLDLNRTGFVQECQSSGTVSYF 160

  Fly   218 RYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIR 282
            .|...||.:..|.:.|.|:|.:.|||:..:...|..:.:||.::|||::|||||||.||.|.|||
Mouse   161 WYRQTLNITSDISNTGTIQWKLFLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIR 225

  Fly   283 GLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALL 347
            ||||||:..|:.|..|||...:....||:|||||:||||...||..:|:||||...||..|||::
Mouse   226 GLTLPGATEGLIYLFTPNMKTLQNPRVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVI 290

  Fly   348 TSFINSATSFIAGFVIFSVLG---------------------------------------YMAHT 373
            .:.:||.||..|...||||:|                                       |:..|
Mouse   291 IALVNSMTSLYASIAIFSVMGFKASNDYGRCLDRNILSLINEFDLPELSISRDEYPSVLMYLNAT 355

  Fly   374 LGVRIE-------------DVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGG 425
            ...|:.             |.:..||||.|:|:..|:..||.::.|:::||.||.||||.|.||.
Mouse   356 QTARVAQLPLKTCHLEDFLDKSASGPGLAFIVFTEAVLHMPGASVWSVLFFGMLFTLGLSSMFGN 420

  Fly   426 SEAIITALSD------EFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSIL 484
            .|.:||.|.|      ..||     |:....:....|:..:....|.|.|:..:.|.:||..:::
Mouse   421 MEGVITPLLDMGILPKGIPK-----EVMTGVICFACFLSAICFTLQSGGYWLEIFDSFAASLNLI 480

  Fly   485 VAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFL--LFITVYGLIGYEPLTY 547
            :..|.|.:.|..|||..||.:||..|.|..||.||||.||.|:|:.|  :|::...|:...|.:|
Mouse   481 IFAFMEVVGVIHIYGMKRFCDDIEWMTGRRPGLYWQVTWRVVSPMLLFGIFLSYIVLLIQTPPSY 545

  Fly   548 -------------ADYVYPSWANALGWCIAGSSV--VMIPAVAIFKLLSTPGSLRQRF--TILTT 595
                         .:..||.|....  |:..|.:  :.:|.||:.:|||   ..:||:  |.|.:
Mouse   546 KAWNPQYEHFPSREEKFYPGWVQVT--CVLLSFLPSLWVPGVALAQLLS---QYKQRWKATHLES 605

  Fly   596 PWRDQQS 602
            ..:.|:|
Mouse   606 GLKLQES 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	225/646 (35%)
Slc6a18	NP_001035782.1	SLC6sbd_B0AT3	16..591	CDD:212086	219/628 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810