DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and Slc6a6

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_030111163.1	Gene:	Slc6a6 / 21366	MGIID:	98488	Length:	631	Species:	Mus musculus

Alignment Length:	619	Identity:	278/619 - (44%)
Similarity:	382/619 - (61%)	Gaps:	43/619 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SKSKTP-TPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGI 71
            |..|:| |..:::.:....:||.||.|:||:|||.|..|.|.||||||||||||||||||:||.|
Mouse    31 SPGKSPGTRPEDEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFI 95

  Fly    72 MLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFF 136
            .|...|:|:|::|:.:||:..:|.||||.::.|||.|||||.::|...::.||.||:||:..:.|
Mouse    96 FLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLF 160

  Fly   137 ASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSA 201
            .||...|||..||:.||||.|.                       ..:|..||::.  .||.|:
Mouse   161 HSFQKDLPWAHCNHSWNTPQCM-----------------------EDTLRRNESHW--VSLSTA- 199

  Fly   202 VGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVW 266
                 .|.|...|::.|.:|.|  |.||.:.|::|||:|||||:|:|:|:|.:|||:.::||||:
Mouse   200 -----NFTSPVIEFWERNVLSL--SSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVY 257

  Fly   267 FTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAY 331
            |||.||:|:||:||:|||||||:..||::||.|:.|.:...:||:||.||:|||.....|.:.:.
Mouse   258 FTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPDISRLGDPQVWIDAGTQIFFSYAICLGAMTSL 322

  Fly   332 ASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAA 396
            .|||||..|.|:|.:|...:||.|||::||.|||:||:||...||.|.|||..||||.|:.||.|
Mouse   323 GSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKA 387

  Fly   397 IATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLYFVV 458
            :..||..|||:::||:|||.|||||.|...|..||:|.|.:|...|   .||:|:|.|.|:.:::
Mouse   388 VTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAILCSISYLL 452

  Fly   459 GLASCTQGGFYFFHLLDRYAA-GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVC 522
            ||...|:||.|.|.|.|.||| |..:|...|||...::||||.:...:.|.||||:.||.:.:..
Mouse   453 GLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYS 517

  Fly   523 WRFVAPIFLLFITVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSL 586
            |..:.|...:...|:.|:.|.||||.. |.||.||..|||.:|.||::.||.|.:..|..|.|.|
Mouse   518 WAVITPALCVGCFVFSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMLCIPLVIVILLCRTEGPL 582

  Fly   587 RQRFTILTTPWRDQQSMAMVLNGVT---TEVTVV 617
            |.|...|.|| |:....|:...|.|   :.||::
Mouse   583 RVRIKYLITP-REPNRWAVEREGATPFHSRVTLM 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	267/574 (47%)
Slc6a6	XP_030111163.1	SLC5-6-like_sbd	51..592	CDD:382020	266/573 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830