DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and Slc6a2

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_033235.3	Gene:	Slc6a2 / 20538	MGIID:	1270850	Length:	617	Species:	Mus musculus

Alignment Length:	584	Identity:	329/584 - (56%)
Similarity:	421/584 - (72%)	Gaps:	31/584 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMEL 85
            :|.:..||||..|:||||||:|||||||||||||||||||||||||:||.:.|::.|:|||||||
Mouse    50 DSDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMEL 114

  Fly    86 ALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNN 150
            ||||:||:||.|.| ::.|.|||:||||:|||.||.|||||||||||.:.|||||.:||||:|.:
Mouse   115 ALGQYNREGAATVW-KICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGH 178

  Fly   151 IWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEY 215
            .||:|||...:..|||   |:|:::. |:.      |..|                    .|:|:
Mouse   179 SWNSPNCTDPKLLNAS---VLGDHTK-YSK------YKFT--------------------PAAEF 213

  Fly   216 FNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILL 280
            :.|.:|.|:.|.||||:|..:|.:.|||::|.::.|||||||:.|||||||.||..||.||.:||
Mouse   214 YERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLL 278

  Fly   281 IRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDA 345
            :.|:||||:..||..||..:|..:.:|.||:|||||:|||||.|||||:|:|||||:.||.|:||
Mouse   279 VHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDA 343

  Fly   346 LLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIF 410
            ||||.||..||||:||.|||:||||||...|.||||||||.||||::||.||:|:..|||||::|
Mouse   344 LLTSTINCVTSFISGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVLF 408

  Fly   411 FMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLD 475
            |:|||.||||||.||.||:||.|:|:|..:||:|:||...:....|::.|...|:||.|...|||
Mouse   409 FLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCVVTISTFLLALFCITKGGIYVLTLLD 473

  Fly   476 RYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLI 540
            .:|||.|||.||..|||.|||.||.:|||.||:.|:||.||.||::||:||:|.||||:.|..:|
Mouse   474 TFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSII 538

  Fly   541 GYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQSMA 604
            .::||||.||.||.|||.:||.||.||::::||..|:|.||..|||.:|.....||..:...:|
Mouse   539 NFKPLTYDDYTYPPWANWVGWGIALSSMILVPAYVIYKFLSIRGSLWERVAYGITPENEHHLVA 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	326/569 (57%)
Slc6a2	NP_033235.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
Slc6a2	NP_033235.3	SLC5-6-like_sbd	56..615	CDD:382020	328/578 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	665	1.000	Domainoid score	I155
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H816
Inparanoid	1	1.050	675	1.000	Inparanoid score	I725
Isobase	1	0.950	-	0	Normalized mean entropy	S2872
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		otm43817
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2688
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.860