DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and snf-10

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_505682.2	Gene:	snf-10 / 191769	WormBaseID:	WBGene00004909	Length:	673	Species:	Caenorhabditis elegans

Alignment Length:	608	Identity:	150/608 - (24%)
Similarity:	245/608 - (40%)	Gaps:	110/608 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 KSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLC--YKNGGGAFLVPYGI 71
            ||.|....:|.......|..||:.|.:.:.:.:.|.....|:|.|||||  |   ||.|...:..
Worm    59 KSVTNLALENIGLDTKMEGPTWTSKWEAITATLSFVTCSGNIWFFPYLCGYY---GGWFPYQFTF 120

  Fly    72 MLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFF- 135
            ..|...:||.|:|.||||:.....::.:.|:.|...|:...:..|..:.....:|...:.|..|
Worm   121 CYVFIAVPLLYLETALGQYASASPLSVFSRMAPAMAGLSAGMCFIMVFRTISLSVWAIYDLTIFT 185

  Fly   136 --FASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMN-GSSL 197
              ..|..::.||.||.           |||:       |:|...|.:.::.     |::. ||..
Worm   186 HASQSIWSTSPWESCQ-----------ESQS-------GDYCVNYKLSSKC-----TWIQPGSDK 227

  Fly   198 DTSAVGHV----EGFQSAASEYFNRYI--LELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWK 256
            :......:    .|||...|.:.: ::  |...||..::|     |:......|:..:|.:.:..
Worm   228 ECDEYQEMLIATRGFQQRKSPFMS-FVHGLMYKRSITMND-----WEPPSVTSIICAVCLWIIIG 286

  Fly   257 GISTSG-KVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPN-----FSA-IYKAE------ 308
            .||..| ||:..|.:....:||:         |:.:.:.|.::.|     |:| .|::|
Worm   287 IISIGGSKVLGRTGIVALTLLLV---------GTIMLLSYGMSLNDTTNVFTAFFYQSEGYEDKW 342

  Fly   309 ----VWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLG- 368
                .|.|||.....:|..|.|.:..:||.|.:||.:::|.||.|.::.......|.:.|..:.
Worm   343 MWVWSWADAAAHALRALNVGCGGIQKFASLNNFHNKIHRDVLLISIVSFVFYICTGLLSFMFMAE 407

  Fly   369 -----YMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEA 428
                 |.......||:..||  |.::..|....:......:.|..:|:   |||...|..|.|..
Worm   408 IGRLYYPDLEASERIQLYAT--PVMIESVISEILTNSSMGSIWVFLFW---LTLAACSIQGISSY 467

  Fly   429 IITALSDEFPKIKRNRELFVAGLFS---------LYFVVGLASCT----QGGFYFFHLLDRYAAG 480
            |....|....::..:|..:...|.|         :..|.||.|..    .||......::.:|:
Worm   468 IWVISSMIVERLNGSRRKYGKALASWHKRAIILAIMSVTGLISSLPFLGNGGINLMSSIETFAS- 531

  Fly   481 YSILVAVFFEAIAVSWIYGTNRFSEDIRDMIG--FPPGRYWQVCWRFVAPIFLL-----FITVYG 538
            |..:...|.|.|.||::||..|||.:||.|||  .||..:|.:.|..::||.|:     .:..:|
Worm   532 YGTIFIAFVEVITVSYVYGFKRFSVNIRAMIGGHGPPNVFWWLNWLVISPILLIVTFGCIVATFG 596

  Fly   539 --------LIGYEPLTYADYVYP 553
                    .|..:|:.|:..|.|
Worm   597 QKKAFNENSIVSDPIGYSLLVMP 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	145/590 (25%)
snf-10	NP_505682.2	SNF	78..628	CDD:264495	145/589 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810