Protein Alignment DAT and snf-12

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_509527.1
• Gene: snf-12 / 181143
• WormBaseID: WBGene00004911
• Length: 1022
• Species: Caenorhabditis elegans
• Alignment Length: 656
• Identity: 187/656 - (28%)
• Similarity: 322/656 - (49%)
• Gaps: 107/656 - (16%)

  Fly    24 SDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALG 88
            :|.||.|..:.||.||.:||.|.:.:..|||...|::|||.|.:||...|:..|:||.::.|:||
 Worm   154 NDRRELWRTQKDFFLSCLGFMVGVGHTMRFPAKVYQHGGGVFFIPYLFSLIFFGLPLVFLHLSLG 218

  Fly    89 QHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFAS-----FTNSLPWTSC 148
            |:..:.|.|.:.||:|:..|:|:|:|:||..|..|||:|:||::.:||.|     ..:.|||.:|
 Worm   219 QYTGQAANTAFQRLMPIGSGVGWALVVIAIPVAVYYNIIVAWAIHYFFQSAKGLLLGDELPWETC 283

  Fly   149 NNIWNTPN--CRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSA 211
            .:.|...|  |               |..:|::..|               .|:::       :|
 Worm   284 RDEWQLDNRCC---------------NLHNLHSCFN---------------STNSI-------TA 311

  Fly   212 ASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVL 276
            ...:|:..:|.|: :.|...||.::..:.|.|...:|:.:|.::||:.:..:.:..||..||.:|
 Worm   312 PEAFFHSEVLSLS-TFGDFALGPLQSHLVLSLAAAWLLVFFGVFKGLGSIAQTMNVTATVPYLLL 375

  Fly   277 LILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNV 341
            .|||:||::|||:..|:.:..|.:.:.::|.::|..||.|||:.||...|.|::.|::::|.||:
 Worm   376 SILLLRGISLPGANKGLTFLFTVDSTKLWKWQIWKSAAEQVFYELGIDAGPLISMAAFSRYRNNI 440

  Fly   342 YKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGP-GLVFVVYPAAIATMPASTF 405
            |:|::|...:::.||.::|.||||.:|::|......:.||....| .|.|.|||...:.|.....
 Worm   441 YRDSVLLVIMDALTSCLSGMVIFSFVGFIASESNSNVNDVLKHDPLYLSFTVYPGVTSFMYWGGL 505

  Fly   406 WALIFFMMLLTLGLDSSFGGSEAIITALSDEFP---KIKRNR---ELFVAGLFSLYFVVGLASCT 464
            ||.:||.||:...:|:.|...|.|.:|..:.|.   |...||   .|.:||.|     :||..|.
 Worm   506 WATLFFGMLVLAAIDAEFAWLEMIASAFMNHFSMKNKAVENRLLAFLCLAGFF-----LGLPLCA 565

  Fly   465 QGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFP--------------- 514
            |||.:.||.::...|.::...........|.::||.:.:..||..|:..|
 Worm   566 QGGIFVFHAIENLNANWNSFSLALLSVAIVCYVYGIDNYLTDISAMLRVPRIQISKATRLKEKLI 630

  Fly   515 ----PGRYW---QVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIP 572
                ||..:   .:|  |:.|:.|..:.|..::||:.:::|....|.....:.|.:....::::|
 Worm   631 YFFGPGGIYIKFSLC--FICPVILTVLLVASVLGYQRISFAGRPIPIDYEIVAWIVMIGPLLVVP 693

  Fly   573 AVAIFKL--LSTPGS-LRQRFTILTTPWRDQQSMAMVLNGVTTEVTVVRLTDTETAKEPVDVXVR 634
            .||..::  :...|. |:..|.  |:.||:.|                     :.:.||.|:.:|
 Worm   694 LVAFMQIRQIRNEGKLLKSLFD--TSEWRESQ---------------------DDSLEPKDLYMR 735

  Fly   635 PVARFQ 640
            ...:|:
 Worm   736 QSGKFE 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	178/608 (29%)
snf-12	NP_509527.1	SLC6sbd	158..660	CDD:271359	165/546 (30%)