DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and dat-1

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_499043.1	Gene:	dat-1 / 176304	WormBaseID:	WBGene00000934	Length:	615	Species:	Caenorhabditis elegans

Alignment Length:	597	Identity:	325/597 - (54%)
Similarity:	416/597 - (69%)	Gaps:	38/597 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHN 91
            ||.||||:||||||:||||||.|:|||||||:|||||.||:||.||:::.|:|||||||.|||:.
Worm    40 REQWSGKLDFLLSVVGFAVDLGNIWRFPYLCFKNGGGVFLIPYSIMVLLTGVPLFYMELCLGQYY 104

  Fly    92 RKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPN 156
            ||||||.|||:.||||||||.|:|.||||||:||||:||.|.:.:.||:.:|||.||||.:|:|.
Worm   105 RKGAITTWGRICPLFKGIGYCVILTAFYVDFFYNVILAWGLHYLYTSFSFNLPWASCNNSYNSPA 169

  Fly   157 C-RPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYI 220
            | .|..|::.:.         :....|||:...:.                   |||.|||.:..
Worm   170 CYEPHWSEDGTA---------MCRSANQSVSAEKI-------------------SAAEEYFYKGF 206

  Fly   221 LELNRS--------EGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLL 277
            |.|:.:        ..:.|||.::||:||.|.:||||||||:||||.||||||||||||||.||.
Worm   207 LGLHEANAPNSHVIRSVTDLGNVRWDIALSLFVVYLICYFSMWKGIHTSGKVVWFTALFPYVVLG 271

  Fly   278 ILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVY 342
            ||.|||:||||...||:|||.|||..:.:..||.|||||||||||||||||:||:|||.:|||||
Worm   272 ILFIRGVTLPGWQNGIEYYLRPNFEMLKRPSVWQDAATQVFFSLGPGFGVLMAYSSYNDFHNNVY 336

  Fly   343 KDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWA 407
            .|||.|||||.||||::|||||||||||:...|..||.||.|||||||||||.|::|||.:.||:
Worm   337 VDALFTSFINCATSFLSGFVIFSVLGYMSCKSGKPIEAVAQEGPGLVFVVYPEALSTMPYAPFWS 401

  Fly   408 LIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFH 472
            ::||:||:||||||||||||||||.||||||.:|:|||:||..||:.|.|:|:|.||:||.....
Worm   402 VLFFLMLMTLGLDSSFGGSEAIITGLSDEFPILKKNREVFVGCLFAFYMVIGIAMCTEGGILIME 466

  Fly   473 LLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVY 537
            .|..|...:.:|:|||.||:.:::|||..:|..|:::|:||.||.||:.||...||..||.:...
Worm   467 WLIIYGTTWGLLIAVFCEAMVIAYIYGLRQFVHDVKEMMGFRPGNYWKFCWSCAAPFILLSMITS 531

  Fly   538 GLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPG-SLRQRFTILTTPWRDQQ 601
            ..|.|:.|||.||.||:.||.:|...|.|....||.|.|:|.::..| ::.:::..:|.|:|.:.
Worm   532 NFINYQALTYQDYTYPTAANVIGIIFALSGASFIPLVGIYKFVNARGNTISEKWQRVTMPYRKRP 596

  Fly   602 SMAMVLNGVTTE 613
            :....:...||:
Worm   597 NQTEYIPIPTTQ 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	321/579 (55%)
dat-1	NP_499043.1	SLC6sbd_SERT-like_u1	40..591	CDD:271405	321/578 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165775
Domainoid	1	1.000	654	1.000	Domainoid score	I70
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H816
Inparanoid	1	1.050	660	1.000	Inparanoid score	I398
Isobase	1	0.950	-	0	Normalized mean entropy	S2872
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		oto20303
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2688
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750