Protein Alignment DAT and snf-3

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_493910.2
• Gene: snf-3 / 173493
• WormBaseID: WBGene00004902
• Length: 600
• Species: Caenorhabditis elegans
• Alignment Length: 595
• Identity: 226/595 - (37%)
• Similarity: 345/595 - (57%)
• Gaps: 51/595 - (8%)

  Fly     1 MSPTGHISKSKTPTPHD--------NDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLC 57
            |..:.|:     |.|.|        ...:|...:|..|:||.|||:|::.:||.|.|||||||||
 Worm     1 MGTSEHV-----PLPTDEAKAKELEQSQHSEEPDRGQWTGKFDFLMSMVAYAVGLGNVWRFPYLC 60

  Fly    58 YKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDF 122
            ||||||:|||.|.|...:..:|:|.||:.:||:.:|||:..| .:.|||:|:|...|:|||....
 Worm    61 YKNGGGSFLVVYMIFFCLAAVPIFLMEVTVGQYLQKGAMEMW-LMCPLFRGVGIGNVVIAFMCIA 124

  Fly   123 YYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIG--NYSDLYAMGNQSL 185
            |:.||:||::.:..:|.....||.:|||.||...|            |.|  |:::|..:
 Worm   125 YFCVIVAWAMFYMISSIAWVFPWETCNNYWNDATC------------VTGKENFTELARI----- 172

  Fly   186 LYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLIC 250
                     .:|..||.||.   |::..:::.:.:  |:.:..|.:.|.|:|::...:...:||.
 Worm   173 ---------KALVASAGGHT---QTSVEQFWEKRV--LHDTGDISEFGGIQWELFFIMAAAWLIV 223

  Fly   251 YFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAAT 315
            ||:|||||:.:.|.|:|.|||||.::.|||||||||.|:..||.:||.||.:.:....||.||.|
 Worm   224 YFALWKGITQARKFVYFCALFPYVLIFILLIRGLTLEGAGTGIYFYLKPNATRLLDTAVWKDAGT 288

  Fly   316 QVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIED 380
            |||:|.|.|||.|:|..|:||:::|.:|||:...|||..||..|||.:||:||||:|.....|.:
 Worm   289 QVFYSYGVGFGALIALGSHNKFNHNCFKDAITMCFINGCTSITAGFAVFSILGYMSHVAQKDISE 353

  Fly   381 VATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRE 445
            :...|.||.|:.||...:.:|....:|::||:|:..|||||.....|.:.|||.|.||.:::.::
 Worm   354 IVKPGVGLAFLAYPEVASNLPMKQVFAVLFFLMITILGLDSQVCMMEGLFTALEDAFPILRKYKK 418

  Fly   446 LFVAGLFSL-YFVVGLASCTQGGFYFFHLLDRY-AAGYSILVAVFFEAIAVSWIYGTNRFSEDIR 508
            ..: |:|.| :|.:|:...|..|.::..|.|.| |:||::|..||||.:.:::.:|.:...:.:.
 Worm   419 QSL-GIFCLFFFCIGIPMVTHSGSHWLTLFDAYGASGYALLFVVFFEVVGLAYGFGAHNIRKALH 482

  Fly   509 DMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIP 572
            :|||....:..:..|:|.||...|.:.|:.::.|.|:.|.| ..:|.||||.||.::..|:|:||
 Worm   483 EMIGVTLPKGIEYVWKFCAPATSLVLFVFCVVYYHPVKYPDGKDFPFWANAFGWFLSSCSMVVIP 547

  Fly   573 AVAIFKLLST 582
            ..||:.|..|
 Worm   548 GYAIYYLFFT 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	220/561 (39%)
snf-3	NP_493910.2	SLC6sbd-TauT-like	30..571	CDD:271387	220/561 (39%)