DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and Slc6a4

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_034614.2	Gene:	Slc6a4 / 15567	MGIID:	96285	Length:	630	Species:	Mus musculus

Alignment Length:	573	Identity:	294/573 - (51%)
Similarity:	395/573 - (68%)	Gaps:	38/573 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            |||||..|:||||||||:||||.|:|||||:||:|||||||:||.||.:.||||||||||||||:
Mouse    78 ERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQY 142

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            :|.|.|:.|.::.|:|||||||:.:||||:..|||.||||:|.:..:|||:.||||||.|.|||.
Mouse   143 HRNGCISIWKKICPIFKGIGYAICIIAFYIASYYNTIIAWALYYLISSFTDQLPWTSCKNSWNTG 207

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYI 220
            ||.              ||   :|..|.:...:.|                   |.|.|::.|::
Mouse   208 NCT--------------NY---FAQDNITWTLHST-------------------SPAEEFYLRHV 236

  Fly   221 LELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLT 285
            |::::|:|:.|||.|.|.:|||:::::.|.|||:|||:.|||||||.||.|||.||.:||:||.|
Mouse   237 LQIHQSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGAT 301

  Fly   286 LPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSF 350
            |||::.|:.:||.||:..:.:..||||||.|:|||||||||||||:|||||::||.|:|||:||.
Mouse   302 LPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSV 366

  Fly   351 INSATSFIAGFVIFSVLGYMAHTLGVRIEDVATE-GPGLVFVVYPAAIATMPASTFWALIFFMML 414
            :|..|||::|||||:||||||......:.:||.: ||.|:|:.|..|||.||||||:|:|||:||
Mouse   367 VNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLML 431

  Fly   415 LTLGLDSSFGGSEAIITALSDEFPKI-KRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYA 478
            :||||||:|.|.|.:|||:.||||.| .:.||.||..:.....:..|.:.|.||.|...||:.||
Mouse   432 ITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCILGSLLTLTSGGAYVVTLLEEYA 496

  Fly   479 AGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYE 543
            .|.::|.....||:.|||.||..:|..|:::|:||.||.:|::||..::|:|||||....|:...
Mouse   497 TGPAVLTVALIEAVVVSWFYGITQFCSDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPP 561

  Fly   544 PLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTP 596
            .|....|.||.|:..||:||..|||:.||...|::|:||||:|::|.....||
Mouse   562 QLRLFQYNYPHWSIILGYCIGTSSVICIPIYIIYRLISTPGTLKERIIKSITP 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	293/572 (51%)
Slc6a4	NP_034614.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..63
		5HT_transport_N	24..64	CDD:281488
		SLC6sbd_SERT	79..615	CDD:271399	293/572 (51%)
		Interaction with RAB4A. /evidence=ECO:0000250	616..624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.730