DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and Slc6a13

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001366036.1	Gene:	Slc6a13 / 14412	MGIID:	95629	Length:	602	Species:	Mus musculus

Alignment Length:	606	Identity:	272/606 - (44%)
Similarity:	380/606 - (62%)	Gaps:	43/606 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            |||.|:.|::|:|||.|..:.|.|||||||||||||||||.:||.|.|...|||:|::|.||||:
Mouse    31 EREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQY 95

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            ..:|.||.|.|:.|:|:|||||..:|...::.||.|::||:|.:.|:|||..|||.||::.|||.
Mouse    96 TNQGGITAWRRICPIFEGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTE 160

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYI 220
            ||..|:..|.|                         ||.:|         |...|...|::.|.:
Mouse   161 NCVEFQKANDS-------------------------MNVTS---------ENATSPVIEFWERRV 191

  Fly   221 LELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLT 285
            |:|  |:||..||:::|::.||||:.::||||.:|||:.::||||:|||.|||.:|::|||||:|
Mouse   192 LKL--SDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVT 254

  Fly   286 LPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSF 350
            |||:..|||:||.||.:.::..:||:||.||:|||.....|.|.|..||||||||.|:|.:....
Mouse   255 LPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCI 319

  Fly   351 INSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLL 415
            :||:|||:|||.|||:||:|:...||.|.:||..||||.|:.||.|:..:|.|..||..||.|::
Mouse   320 LNSSTSFMAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVV 384

  Fly   416 TLGLDSSFGGSEAIITALSDEFPKI---KRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRY 477
            .|||||.|...|:::|||.|.:|::   |..||:.:..:..:.|.:||...|:||.|.|.|.|.|
Mouse   385 LLGLDSQFVCVESLVTALVDMYPRVFRKKNRREVLILIVSVISFFIGLIMLTEGGMYVFQLFDYY 449

  Fly   478 AA-GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIG 541
            || |..:|....||::.|:|:||..||.::|.||||:.|....:.||.|..|...|...::.||.
Mouse   450 AASGMCLLFVAIFESLCVAWVYGAGRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIK 514

  Fly   542 YEPLTY-ADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD--QQSM 603
            |.|||| ..|.||.|.:||||.:|.||::.|||.:|:||.:..|.||:|...|..|..|  |::.
Mouse   515 YTPLTYNKKYTYPWWGDALGWLLALSSMICIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKNQ 579

  Fly   604 AMVLNGVTTEVTVVRLTDTET 624
            .......|...:::|||:.|:
Mouse   580 PEPTAPATPMTSLLRLTELES 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	263/574 (46%)
Slc6a13	NP_001366036.1	SLC5-6-like_sbd	32..575	CDD:382020	265/578 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830