DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and Slc6a12

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001368835.1	Gene:	Slc6a12 / 14411	MGIID:	95628	Length:	628	Species:	Mus musculus

Alignment Length:	576	Identity:	254/576 - (44%)
Similarity:	364/576 - (63%)	Gaps:	40/576 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            :|..|:.|::|:|||.|..:.|.|||||||||||||||||.:||.|.....|||:|::|:||||:
Mouse    49 DRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQY 113

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            :.:|::|.|.::.||.:|||.|.|:|..|::.||.:|:||:|.:.|:|||..||||:|.|.|||.
Mouse   114 SSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTE 178

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYI 220
            :|..|.:.:::|                                 .|...|.|.|...|::.|.:
Mouse   179 HCVDFLNHSSAR---------------------------------GVSSSENFTSPVMEFWERRV 210

  Fly   221 LELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLT 285
            |.:  :.||||||:::|::|||||:.::||||.:|||:.::||||:|||.|||.:|:||||||:|
Mouse   211 LGI--TSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVT 273

  Fly   286 LPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSF 350
            |||::.||.:||.|:...:...:||:||.||:|||.....|.|.|..||||||||.|:|::...|
Mouse   274 LPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCF 338

  Fly   351 INSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLL 415
            :||||||:||||:||:||:|:...|:.|.:||..||||.|:.:|.|:..||.|..|:.:||:|||
Mouse   339 LNSATSFVAGFVVFSILGFMSQEQGIPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLL 403

  Fly   416 TLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRY 477
            .|||||.|...|.::||..|.||:..|   .|||.:..:..|.:::||...|:||.|.|.|.|.|
Mouse   404 FLGLDSQFVCMECLVTASMDMFPQQLRKSGRRELLILAISVLCYLMGLLLVTEGGMYIFQLFDYY 468

  Fly   478 A-AGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIG 541
            | :|..:|....||.|.:.|:||.:||.:::.||||:.|....::.|.|:.|...|....:.|..
Mouse   469 ASSGICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSK 533

  Fly   542 YEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTP 596
            |.||.|.: |:||||..::||.:|.||:..:|...|...|.|.||.::|...|.||
Mouse   534 YTPLKYNNVYMYPSWGYSIGWLLAFSSMACVPLFIIITFLKTQGSFKKRLRRLITP 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	254/575 (44%)
Slc6a12	NP_001368835.1	SLC5-6-like_sbd	49..589	CDD:382020	252/574 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.830