DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DAT and Slc6a3

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_034150.1	Gene:	Slc6a3 / 13162	MGIID:	94862	Length:	619	Species:	Mus musculus

Alignment Length:	591	Identity:	315/591 - (53%)
Similarity:	411/591 - (69%)	Gaps:	36/591 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            ||||||.|:|||||||||||||||||||||||||||||||||||.:.:|:.|:|||||||||||.
Mouse    59 ERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQF 123

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            ||:||...| ::.|:.||:|:.|:||:|||.|:|||||||:|.:||:|||..|||..|||.||:|
Mouse   124 NREGAAGVW-KICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSP 187

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYI 220
            ||....|.|:|                ..|..|:|:  |:              :.|:|||.|.:
Mouse   188 NCSDAHSSNSS----------------DGLGLNDTF--GT--------------TPAAEYFERGV 220

  Fly   221 LELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLT 285
            |.|::|.||.|||..:|.:..||::|.::.|||||||:.|||||||.||..||.||..||:||:|
Mouse   221 LHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVT 285

  Fly   286 LPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSF 350
            |||:..||:.||:.:|..:.:|.||:||||||.||||.|||||:|::||||:.||.|:||::|:.
Mouse   286 LPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTS 350

  Fly   351 INSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLL 415
            |||.|||.:|||:||.|||||....|.|.||||:||||:|::||.||||:|.|:.||.:||:|||
Mouse   351 INSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLL 415

  Fly   416 TLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAG 480
            |||:||:.||.|::||.|.|||..:.|:||||..|:....|::.|...|.||.|.|.|||.:|||
Mouse   416 TLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG 480

  Fly   481 YSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPL 545
            .|||..|..|||.|:|.||..:||:||:.|.|..|..||::||:.|:|.|||::.|..::.:.|.
Mouse   481 TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPP 545

  Fly   546 TYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQSMAMVLNGV 610
            .|..|::|.|||||||.||.||:.|:|..|.:|..|.|||.|::.....||.:|:|   :|..|.
Mouse   546 HYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDRQ---LVDRGE 607

  Fly   611 TTEVTV 616
            ..:.|:
Mouse   608 VRQFTL 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	308/569 (54%)
Slc6a3	NP_034150.1	SLC5-6-like_sbd	60..613	CDD:294310	313/588 (53%)
Slc6a3	NP_034150.1	Interaction with TGFB1I1. /evidence=ECO:0000250	560..589		15/28 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	665	1.000	Domainoid score	I155
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	675	1.000	Inparanoid score	I725
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53371
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		otm43817
orthoMCL	1	0.900	-	-		OOG6_101590
Panther	1	1.100	-	-	O	PTHR11616
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840