DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and Slc6a7

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_446448.2	Gene:	Slc6a7 / 117100	RGDID:	620928	Length:	637	Species:	Rattus norvegicus

Alignment Length:	641	Identity:	279/641 - (43%)
Similarity:	391/641 - (60%)	Gaps:	51/641 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 HISKSKTP----TPHDNDNNSI----SDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGG 62
            |:.|..||    ||.|..:..:    :.:|..|:||:|||||.||:.|.|.|||||||..|.|||
  Rat     8 HLRKPVTPDLLMTPSDQGDVDLDVDFAADRGNWTGKLDFLLSCIGYCVGLGNVWRFPYRAYTNGG 72

  Fly    63 GAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVI 127
            |||||||.:||.:.|||||::||:|||.:..|.:..| ::.|||||.|.|::||...|..|||:|
  Rat    73 GAFLVPYFLMLAICGIPLFFLELSLGQFSSLGPLAVW-KISPLFKGAGAAMLLIVGLVAIYYNMI 136

  Fly   128 IAWSLRFFFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYM 192
            ||:.|.:.|||.|::|||..|.|.|||..|.      ..|.|..||       |...|..:.|.
  Rat   137 IAYVLFYLFASLTSNLPWEHCGNWWNTERCL------EHRGPKDGN-------GALPLNLSSTV- 187

  Fly   193 NGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKG 257
                             |.:.||::||:|.:..|:||...|.|:|::.||||:.::|.:..:.||
  Rat   188 -----------------SPSEEYWSRYVLHIQGSQGIGRPGEIRWNLCLCLLLAWVIVFLCILKG 235

  Fly   258 ISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLG 322
            :.:|||||:|||.|||.:||:||:||:||||::.|||:||||.|..:..::||::||.|:|:|||
  Rat   236 VKSSGKVVYFTATFPYLILLMLLVRGVTLPGAWKGIQFYLTPQFHHLLSSKVWIEAALQIFYSLG 300

  Fly   323 PGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPG 387
            .|||.||.:||||.:|.|:|:|..:.:..|:.||.:|||.||||||||:..|||.::.||..|||
  Rat   301 VGFGGLLTFASYNTFHQNIYRDTFIVTLGNAITSILAGFAIFSVLGYMSQELGVPVDQVAKAGPG 365

  Fly   388 LVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLF 452
            |.|||||.|:..:|.|.||:.:||.|||||||||.|...|.|:||::||||...|.::...:||.
  Rat   366 LAFVVYPQAMTMLPLSPFWSFLFFFMLLTLGLDSQFAFLETIVTAVTDEFPYYLRPKKAVFSGLI 430

  Fly   453 SL-YFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPG 516
            .: .:::||...|.||.|:..|||.|:|.:.::|.|....:||:.:||..||..||..|:||.||
  Rat   431 CVAMYLMGLILTTDGGMYWLVLLDDYSASFGLMVVVITTCLAVTRVYGIQRFCRDIHMMLGFKPG 495

  Fly   517 RYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLS 581
            .|::.||.|::|..||.:.||.::.|:|..|..|.:|:||..||..:...|.:||||..:..:|.
  Rat   496 LYFRACWLFLSPATLLALLVYSIVKYQPSEYGSYRFPAWAELLGILMGLLSCLMIPAGMLVAVLR 560

  Fly   582 TPGSLRQRFTILTTP---WRDQQSMAMVLNGVTTEVTVVRLTDTETAKEPVDVXVR 634
            ..|||.:|....:.|   |...      |....|.:.|..|..:::.| |:.|.:|
  Rat   561 EEGSLWERLQQASRPAIDWGPS------LEENRTGMYVATLAGSQSPK-PLMVHMR 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	263/573 (46%)
Slc6a7	NP_446448.2	SLC5-6-like_sbd	37..581	CDD:382020	264/575 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820