DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and Slc6a9

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_006238687.1	Gene:	Slc6a9 / 116509	RGDID:	621243	Length:	638	Species:	Rattus norvegicus

Alignment Length:	609	Identity:	258/609 - (42%)
Similarity:	374/609 - (61%)	Gaps:	42/609 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ISKSKTPTPHDNDNNSISDE---------RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGG 62
            ::.....|.....|.::..|         |..|..:::|:|:.:|:||.|.||||||||||:|||
  Rat     3 VAHGPVATSSPEQNGAVPSEATKKDQNLTRGNWGNQIEFVLTSVGYAVGLGNVWRFPYLCYRNGG 67

  Fly    63 GAFLVPYGIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVI 127
            |||:.||.||||..|||||:|||:.||...:|.:..| |:.|:|||:||.:::::.|:..||||:
  Rat    68 GAFMFPYFIMLVFCGIPLFFMELSFGQFASQGCLGVW-RISPMFKGVGYGMMVVSTYIGIYYNVV 131

  Fly   128 IAWSLRFFFASFTNSLPWTSCNNIWNTPNCR----PFESQNASRVPVIGNYSDLYAMGNQSLLYN 188
            |..:..:||:|.|:.|||..|||.||||:|.    .....|.||...:.        ||.|.|:|
  Rat   132 ICIAFYYFFSSMTHVLPWAYCNNPWNTPDCAGVLDASNLTNGSRPTALS--------GNLSHLFN 188

  Fly   189 ETYMNGSSLDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFS 253
            .|...               .|.:.||:..|:|:|  |:.|.|.|.::..:..||.:.:::.:..
  Rat   189 YTLQR---------------TSPSEEYWRLYVLKL--SDDIGDFGEVRLPLLGCLGVSWVVVFLC 236

  Fly   254 LWKGISTSGKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVF 318
            |.:|:.:|||||:|||.|||.||.||.:||:||.|:|.||.|||||.:..|.:|:||.|||:|:|
  Rat   237 LIRGVKSSGKVVYFTATFPYVVLTILFVRGVTLEGAFTGIMYYLTPKWDKILEAKVWGDAASQIF 301

  Fly   319 FSLGPGFGVLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVAT 383
            :|||..:|.|:..|||||:|||.|:|:::.|..|.|||..|||||||:||:||:.|||.:..||.
  Rat   302 YSLGCAWGGLITMASYNKFHNNCYRDSVIISITNCATSVYAGFVIFSILGFMANHLGVDVSRVAD 366

  Fly   384 EGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK--IKRNREL 446
            .||||.||.||.|:..:|.|..|:|:||.||:.|||.:.|...|.::||:.||...  |.:.:..
  Rat   367 HGPGLAFVAYPEALTLLPISPLWSLLFFFMLILLGLGTQFCLLETLVTAIVDEVGNEWILQKKTY 431

  Fly   447 FVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMI 511
            ...|:....|::|:...:|.|.|:..|:|.|||.:|::|......:::.:|||...:.:||:.|:
  Rat   432 VTLGVAVAGFLLGIPLTSQAGIYWLLLMDNYAASFSLVVISCIMCVSIMYIYGHRNYFQDIQMML 496

  Fly   512 GFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAI 576
            ||||..::|:|||||:|..:.||.::.:|.|.|:||..|.||.||.|:|:.:|.|||:.||..|:
  Rat   497 GFPPPLFFQICWRFVSPTIIFFILIFTVIQYRPITYNHYQYPGWAVAIGFLMALSSVICIPLYAL 561

  Fly   577 FKLLSTPG-SLRQRFTILTTPWRD 599
            |:|..|.| :|.||....|.|.||
  Rat   562 FQLCRTDGDTLLQRLKNATKPSRD 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	252/576 (44%)
Slc6a9	XP_006238687.1	SLC6sbd_GlyT1	16..599	CDD:212067	257/596 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820