Protein Alignment DAT and Slc6a20

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_579830.1
• Gene: Slc6a20 / 113918
• RGDID: 621651
• Length: 616
• Species: Rattus norvegicus
• Alignment Length: 643
• Identity: 220/643 - (34%)
• Similarity: 319/643 - (49%)
• Gaps: 127/643 - (19%)

  Fly     8 SKSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIM 72
            |:.:.|.|.:.....:...|..|...:.|:.:.|.:||.|.|||||||||...|||:|||||.||
  Rat    10 SRGQRPGPDEKRARDMEKARPQWGNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYLIM 74

  Fly    73 LVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFA 137
            |:|.|:||.|:|||:||..|:|:|..|..:.|...|:|.|.|:::|::..|||||.||...:.|.
  Rat    75 LIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFH 139

  Fly   138 SFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAV 202
            ||.:.|||:.|                                               .|:::..
  Rat   140 SFQDPLPWSVC-----------------------------------------------PLNSNRT 157

  Fly   203 GHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWF 267
            |:.|..:.|:|..:..|...||.|..|.:.|.::|:.||||.:.:|:.|..:.:|..::||||:|
  Rat   158 GYDEECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLCILRGTESTGKVVYF 222

  Fly   268 TALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYA 332
            |||.||.||:|.|:|||||.|:..|:.|..||....:...:.|::||||:|||||.|||.|:|:|
  Rat   223 TALMPYCVLIIYLVRGLTLHGATNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFA 287

  Fly   333 SYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLG----------------------------- 368
            |||:..|:..|.|::.|.|||:||..|..|.||:.|
  Rat   288 SYNEPSNDCQKHAVIVSVINSSTSIFASIVTFSIYGFKATFNYENCLNKVILLLTNSFDLEDGFL 352

  Fly   369 ----------YMAHTLGVRIEDV---------------ATEGPGLVFVVYPAAIATMPASTFWAL 408
                      |:|.|...:..:|               |.:|.||.|:||..||..|..|..|::
  Rat   353 TASNLEEVKDYLASTYPNKYSEVFPHIRNCSLESELNTAVQGTGLAFIVYAEAIKNMEVSQLWSV 417

  Fly   409 IFFMMLLTLGLDSSFGGSEAIITALSDE------FPKIKRNRELFVAGLFSLY-FVVGLASCTQG 466
            ::|.|||.||:.|..|.:.||:|.|:|.      .||..      ::||..|. ..||:....:.
  Rat   418 LYFFMLLMLGMGSMLGNTAAILTPLTDSKVISSYLPKEA------ISGLVCLINCAVGMVFTMEA 476

  Fly   467 GFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAP--- 528
            |.|:|.:.:.|||..|:|:.|..|.|||.::||..||..|:|.|.|.|...||:..|.||:|
  Rat   477 GNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLRAMTGRPLNWYWKAMWAFVSPLLI 541

  Fly   529 --IFLLFITVY---GLIGYE--PLTYADYV---YPSWANALGWCIAGSSVVMIPAVAI 576
              :|:.:::.|   |.:.|:  ..|....|   ||..|.|:...:..||.:.||.||:
  Rat   542 IGLFIFYLSDYILTGTLQYQAWDATQGQLVTKDYPPHALAVIGLLVASSTMCIPLVAL 599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	217/624 (35%)
Slc6a20	NP_579830.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		3/15 (20%)
		SLC5-6-like_sbd	26..601	CDD:294310	217/627 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810