Protein Alignment DAT and SLC6A14

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_009162.1
• Gene: SLC6A14 / 11254
• HGNCID: 11047
• Length: 642
• Species: Homo sapiens
• Alignment Length: 597
• Identity: 264/597 - (44%)
• Similarity: 367/597 - (61%)
• Gaps: 40/597 - (6%)

  Fly    17 DNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLF 81
            :||.|   .:|..||.|.|:|||:||:||.|.||||||||.|.|||||||:||.|||.:.|:|||
Human    29 ENDEN---QDRGNWSKKSDYLLSMIGYAVGLGNVWRFPYLTYSNGGGAFLIPYAIMLALAGLPLF 90

  Fly    82 YMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWT 146
            ::|.:|||....|.::.| |::|||:|:|..:|||:.:|..|||||||:||.:.||||.:.|||.
Human    91 FLECSLGQFASLGPVSVW-RILPLFQGVGITMVLISIFVTIYYNVIIAYSLYYMFASFQSELPWK 154

  Fly   147 SCNNIWNTPNCRPFESQNASRVPVIG--NYSDLYAMGNQSLLY---------NETYMNGSSLDTS 200
            :|:: |:..||        ||.|::.  |.|.: ..|.|.::.         |.|.:|||.:
Human   155 NCSS-WSDKNC--------SRSPIVTHCNVSTV-NKGIQEIIQMNKSWVDINNFTCINGSEI--- 206

  Fly   201 AVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVV 265
                .:..|..:.:|:|:  :.|.||.|:::.|.|.|.:|||||:.:||...:|:|||.:|||||
Human   207 ----YQPGQLPSEQYWNK--VALQRSSGMNETGVIVWYLALCLLLAWLIVGAALFKGIKSSGKVV 265

  Fly   266 WFTALFPYAVLLILLIRGLTLPGSFLGIQYYL--TPNFSAIYKAEVWVDAATQVFFSLGPGFGVL 328
            :|||||||.||||||:||.||.|:..||.||:  ..||:.:.:||||.|||||:|:||...:|.|
Human   266 YFTALFPYVVLLILLVRGATLEGASKGISYYIGAQSNFTKLKEAEVWKDAATQIFYSLSVAWGGL 330

  Fly   329 LAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVY 393
            :|.:||||:.||.:.||::....|..||..|||.|||:||:|||..|..:..|...|..|.|:.|
Human   331 VALSSYNKFKNNCFSDAIVVCLTNCLTSVFAGFAIFSILGHMAHISGKEVSQVVKSGFDLAFIAY 395

  Fly   394 PAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKI-KRNRELFVAGLFSLYFV 457
            |.|:|.:|...||:::||.|||||||||.|...|.|.|.:.|.|||: |:.|.....|...:.|:
Human   396 PEALAQLPGGPFWSILFFFMLLTLGLDSQFASIETITTTIQDLFPKVMKKMRVPITLGCCLVLFL 460

  Fly   458 VGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPP---GRYW 519
            :||...||.|.|:.||:|.:.||:.||:|...|.:.:.||||.|||.||...|||...   ..:|
Human   461 LGLVCVTQAGIYWVHLIDHFCAGWGILIAAILELVGIIWIYGGNRFIEDTEMMIGAKRWIFWLWW 525

  Fly   520 QVCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPG 584
            :.||..:.||.|:.|.::.|:.:....|....||.|..|||||:....::.||.:||.|::...|
Human   526 RACWFVITPILLIAIFIWSLVQFHRPNYGAIPYPDWGVALGWCMIVFCIIWIPIMAIIKIIQAKG 590

  Fly   585 SLRQRFTILTTP 596
            ::.||......|
Human   591 NIFQRLISCCRP 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	261/587 (44%)
SLC6A14	NP_009162.1	SLC6sbd_ATB0	36..641	CDD:271391	261/587 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	622..642

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820