DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and Slc6a5

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_006540608.1	Gene:	Slc6a5 / 104245	MGIID:	105090	Length:	831	Species:	Mus musculus

Alignment Length:	599	Identity:	271/599 - (45%)
Similarity:	390/599 - (65%)	Gaps:	17/599 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 GHISKSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPY 69
            |.::.:..|.....|.|.   .|..||.|:||:||::|:||.|.||||||||.::|||||||:||
Mouse   206 GSVATTTIPEDEQGDENK---ARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPY 267

  Fly    70 GIMLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRF 134
            .:||.:.|:|:|::|::|||...:|.::.| :.:|..:|.|.|:::|:..:..||||||.::|.:
Mouse   268 LMMLALAGLPIFFLEVSLGQFASQGPVSVW-KAIPALQGCGIAMLIISVLIAIYYNVIICYTLFY 331

  Fly   135 FFASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGN---QSLLYNETYMNGSS 196
            .||||.:.|||.||||.||||.|:. :::......|||::..:....:   .:...|.|.:|.:|
Mouse   332 LFASFVSVLPWGSCNNPWNTPECKD-KTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTS 395

  Fly   197 LDTSAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTS 261
            .....      |.|.:.|||..::|::  |.||...|.|:|.:|.||.:.::|.|.||.|||.:|
Mouse   396 QTNKT------FVSGSEEYFKYFVLKI--SAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKSS 452

  Fly   262 GKVVWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFG 326
            ||||:|||.|||.||:||||||:||||:..||.|::||.:..:..|.||.|||||:||||...:|
Mouse   453 GKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWG 517

  Fly   327 VLLAYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFV 391
            .|:..:||||:|||.|:|.|:.:..|||||..||||||||:|:||:...|.||:||.:|||:.||
Mouse   518 GLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFV 582

  Fly   392 VYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPK-IKRNRELFVAGLFSLY 455
            |||.|:..:|.|.|||:|||:||||||||:.|...|.|:|::|||||| ::.::.:|..|....:
Mouse   583 VYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICF 647

  Fly   456 FVVGLASCTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQ 520
            |::|....||||.|.|.|:|.|||.|::::...||.:.:|::||..||.|||..||||.|..:|:
Mouse   648 FIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFKPNIFWK 712

  Fly   521 VCWRFVAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGS 585
            |||.||.|..|.||..:....:||:||..|.||:|:..|||.:...||:.||.:.:.|:...||.
Mouse   713 VCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGR 777

  Fly   586 LRQRFTILTTPWRD 599
            ..:|..::.:|..|
Mouse   778 FIERLKLVCSPQPD 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	265/573 (46%)
Slc6a5	XP_006540608.1	SLC6sbd_GlyT2	225..821	CDD:271389	267/577 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920