Protein Alignment DAT and Slc6a15

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001239259.1
• Gene: Slc6a15 / 103098
• MGIID: 2143484
• Length: 729
• Species: Mus musculus
• Alignment Length: 676
• Identity: 228/676 - (33%)
• Similarity: 348/676 - (51%)
• Gaps: 134/676 - (19%)

  Fly    19 DNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYM 83
            |.:...|||..|:.|:.::|:.:||:|.|.|||||||||.||||||:|:||.|:|:|.|||||::
Mouse    53 DGSEADDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLLVIGIPLFFL 117

  Fly    84 ELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSC 148
            ||::||..|:|:|..|..:.|...|||:|..::.::|..||||||.|:|.:|..||...|||..|
Mouse   118 ELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWTLFYFSQSFQQPLPWDQC 182

  Fly   149 NNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAAS 213
                                |::.|.|..|.                        ..|..||:|:
Mouse   183 --------------------PLVKNASHTYV------------------------EPECEQSSAT 203

  Fly   214 EYF-NRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLL 277
            .|: .|..|::..|  |.|.|.:.|.|.:|||:.:::...::.|||.:|||:::|::||||.||:
Mouse   204 TYYWYREALDITSS--ISDSGGLNWKMTVCLLVAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLI 266

  Fly   278 ILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVY 342
            ..|||.|.|.||..||::..||....:.:.:||.:|||||||:||.|||.::|::||||..||.:
Mouse   267 CFLIRSLLLNGSIDGIRHMFTPKLEMMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCH 331

  Fly   343 KDALLTSFINSATSFIAGFVIFSVLGYMA------------------------------------ 371
            .||:|.||||..||.:|..|:|:|||:.|
Mouse   332 FDAVLVSFINFFTSVLATLVVFAVLGFKANIVNEKCISQNSEMILKLLKMGNISWDVIPHHINLS 396

  Fly   372 -------------------------HTLGVRIED---VATEGPGLVFVVYPAAIATMPASTFWAL 408
                                     |....:|||   .|.:|.||.|:.:..|:...|||.||::
Mouse   397 AVTVEDYRLVYDIIQKVKEEEFAVLHLNACQIEDELNKAVQGTGLAFIAFTEAMTHFPASPFWSV 461

  Fly   409 IFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHL 473
            :||:||:.|||.|.||..|.|||.:.|.|   |..:|:.......|.|.:||....:.|.||..:
Mouse   462 MFFLMLINLGLGSMFGTIEGIITPIVDTF---KVRKEILTVICCLLAFCIGLIFVQRSGNYFVTM 523

  Fly   474 LDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYG 538
            .|.|:|...:|:.|..|.||||::||.::|.||:.||:||.|.:|:...|::::|:.||.:.:..
Mouse   524 FDDYSATLPLLIVVILENIAVSFVYGIDKFIEDLTDMLGFAPSKYYYYMWKYISPLMLLTLLIAS 588

  Fly   539 LI--GYEPLTYADYV----------YPSWANALGWCIAGSSVVMIPAVAIFK----LLSTPGSLR 587
            ::  |..|..|..::          ||.|...:.:.:...:::.:|.|.|.:    :..:.|:|.
Mouse   589 IVNMGLSPPGYNAWIKEKASEEFLSYPMWGMVVCFSLMVLAILPVPVVFIIRRCNLIDDSSGNLA 653

  Fly   588 ----QRFTILTTPWRDQQSMAMVLNG 609
                :|..:|..|...:...|.:::|
Mouse   654 SVTYKRGRVLKEPVNLEGDDASLIHG 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	222/654 (34%)
Slc6a15	NP_001239259.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..61		2/7 (29%)
		SLC6sbd_SBAT1	61..640	CDD:212091	218/627 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820