Protein Alignment DAT and Slc6a20a

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_631881.1
• Gene: Slc6a20a / 102680
• MGIID: 2143217
• Length: 592
• Species: Mus musculus
• Alignment Length: 624
• Identity: 218/624 - (34%)
• Similarity: 311/624 - (49%)
• Gaps: 127/624 - (20%)

  Fly    27 RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHN 91
            |..|...:.|:.:.|.:||.|.|||||||||...|||:|||||.|||:|.|:||.|:|||:||..
Mouse     5 RPQWGHPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYIIMLIVEGMPLLYLELAVGQRM 69

  Fly    92 RKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPN 156
            |:|:|..|..:.|...|:|.|.|:::|::..|||||.||...:.|.||.:.|||:.|
Mouse    70 RQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDPLPWSVC-------- 126

  Fly   157 CRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYIL 221
                        |:..|::                           |:.|..:.|:|..:..|..
Mouse   127 ------------PLNSNHT---------------------------GYDEECEKASSTQYFWYRK 152

  Fly   222 ELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTL 286
            .||.|..|.:.|.::|:.||||.:.:|:.|..:.:|..::||||:|||..||.||:|.|:|||||
Mouse   153 TLNISPSIQENGGVQWEPALCLTLAWLMVYLCILRGTESTGKVVYFTASMPYCVLIIYLVRGLTL 217

  Fly   287 PGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFI 351
            .|:..|:.|..||....:...:.|::||||:|||||.|||.|:|:||||:..||..|.|::.|.|
Mouse   218 HGATNGLMYMFTPKMEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNNCQKHAIIVSII 282

  Fly   352 NSATSFIAGFVIFSVLGYMA--------------------------------------------- 371
            ||:||..|..|.||:.|:.|
Mouse   283 NSSTSIFASIVTFSIYGFKATFNYENCLNKVILLLTNSFDLEDGFLTVSNLEEVKNYLASTYPNK 347

  Fly   372 ------HTLGVRIE---DVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSFGGSE 427
                  |.....:|   |.|.:|.||.|:||..||..|..|..|::::|.|||.||:.|..|.:.
Mouse   348 YSEVFPHIRNCSLESELDTAVQGTGLAFIVYTEAIKNMEVSQLWSVLYFFMLLMLGIGSMLGNTA 412

  Fly   428 AIITALSDE------FPKIKRNRELFVAGLFSLY-FVVGLASCTQGGFYFFHLLDRYAAGYSILV 485
            ||:|.|:|.      .||..      ::||..|. ..||:....:.|.|:|.:.:.|||..|:|:
Mouse   413 AILTPLTDSKVISSYLPKEA------ISGLVCLINCAVGMVFTMEAGNYWFDIFNDYAATLSLLL 471

  Fly   486 AVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAP-----IFLLFITVY---GLIGY 542
            .|..|.|||.::||..||..|:|.|.|.....||:|.|.||:|     :|:.:::.|   |.:.|
Mouse   472 IVLVETIAVCYVYGLKRFESDLRAMTGRTLSWYWKVMWAFVSPLLIVGLFIFYLSDYILTGTLQY 536

  Fly   543 E--PLTYADYV---YPSWANALGWCIAGSSVVMIPAVAI 576
            :  ..|....|   ||..|.|:...:..||.:.||.||:
Mouse   537 QAWDATQGQLVTKDYPPHALAVIGLLVASSTMCIPLVAL 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	218/624 (35%)
Slc6a20a	NP_631881.1	SLC5-6-like_sbd	2..577	CDD:444915	218/624 (35%)