Protein Alignment DAT and slc6a16

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_004916326.1
• Gene: slc6a16 / 100497867
• XenbaseID: XB-GENE-996340
• Length: 677
• Species: Xenopus tropicalis
• Alignment Length: 636
• Identity: 218/636 - (34%)
• Similarity: 316/636 - (49%)
• Gaps: 155/636 - (24%)

  Fly    27 RETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQHN 91
            |.||..||.::|:.:||:|.|.|||||||||::||||:||:.|.::|::.|||||::|||.||..
 Frog    28 RPTWGSKVQYILAQVGFSVGLGNVWRFPYLCHQNGGGSFLLLYFLLLLIIGIPLFFLELAAGQSI 92

  Fly    92 RKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTPN 156
            |:|:|..|..:.|...|||:|..::..:|..||||||.|||.:.|.||...|||.:|
 Frog    93 RQGSIGVWKHISPRLAGIGFASCVVCGFVALYYNVIIGWSLFYLFNSFHYPLPWENC-------- 149

  Fly   157 CRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYIL 221
                        |.:.|.                        |..|  .|..:|:.:.|| .|..
 Frog   150 ------------PTLPNM------------------------TQEV--TECAKSSNTTYF-WYRS 175

  Fly   222 ELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLTL 286
            .||.:..| :...:.|.|..||.:.:.:....:.|||.:||||::|:::|||.||...|||||.|
 Frog   176 ALNVTNTI-ESSEMNWPMTGCLCLAWFLVCGGMIKGIKSSGKVMYFSSVFPYVVLFCFLIRGLLL 239

  Fly   287 PGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSFI 351
            .|:..||:...||........:||..|||||||:||.|||.::||:|||...||.:.||:|.|||
 Frog   240 EGAADGIRIMFTPKLEIWGNIQVWRQAATQVFFALGLGFGSVIAYSSYNDRQNNCHFDAILVSFI 304

  Fly   352 NSATSFIAGFVIFSVLGYMAHTL------------------------------------------ 374
            |..||.:|..|:|:|||:.|:.|
 Frog   305 NFMTSILATLVVFAVLGFRANDLTRHCIDTNREKILYLISNGSLYENIVPMKNLTNSEYSQWYEI 369

  Fly   375 ----------GV---RIEDV---ATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLDSSF 423
                      |:   |:|||   ..||.||.|:.:..|:...|||.||:::||:|||.|||.:.|
 Frog   370 TNNTLNLQQYGISDCRVEDVMNEGVEGTGLAFIAFTEAMTRFPASPFWSILFFLMLLNLGLSTMF 434

  Fly   424 GGSEAIITALSDEFPKIKRNRELF-----VAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAGYSI 483
            |..:.|||.|.|.||.:::.:.:|     :.||     ::||....:.|.||..:.|.|:|...:
 Frog   435 GNMQGIITPLLDNFPYLRKKKTIFTVICCITGL-----LIGLIFVQRSGSYFVSMFDDYSATLPL 494

  Fly   484 LVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPLTYA 548
            ::.|.||.|||:|:||..||.:||..|:|..|.|.::..|:        :|::.|:||   |..|
 Frog   495 IIVVIFENIAVAWVYGAERFMDDIGGMLGHRPWRIYKYIWQ--------YISILGMIG---LLLA 548

  Fly   549 DYV-----------------------YPSWANALGWCIAGSSVVMIPAVAI 576
            ..:                       ||.|  |||..   :|::::.|:.|
 Frog   549 SLIRMCIEYPRYQAWNQEQAKKEMLEYPPW--ALGML---TSLIIVAALPI 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	218/636 (34%)
slc6a16	XP_004916326.1	SLC5-6-like_sbd	28..599	CDD:444915	218/636 (34%)