Protein Alignment DAT and slc6a5

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_031756248.1
• Gene: slc6a5 / 100495275
• XenbaseID: XB-GENE-993852
• Length: 789
• Species: Xenopus tropicalis
• Alignment Length: 592
• Identity: 272/592 - (45%)
• Similarity: 386/592 - (65%)
• Gaps: 27/592 - (4%)

  Fly    17 DNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLF 81
            :.|.|.   .|..||.|:||:||::|:||.|.||||||||.:||||||||:||..||.:.|:|:|
 Frog   176 EGDENK---ARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFKNGGGAFLIPYLTMLALAGLPIF 237

  Fly    82 YMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWT 146
            |||:||||...:|.|:.| :.:|..:|.|.|:::|:..:..|||:|:.:::.:.|||..:.|||.
 Frog   238 YMEVALGQFASQGPISVW-KAIPALQGCGIAMLIISVLIAIYYNIIMCYTIFYLFASLVSVLPWA 301

  Fly   147 SCNNIWNTPNCRPFESQNASRVP----VIGNYSDLYAMGN---QSLLYNETYMNGSSLDTSAVGH 204
            ||.|.||||:|:     :..|:.    :||:..:::...:   .:...|.|.:|.:|       |
 Frog   302 SCTNPWNTPDCK-----DKDRLMLDSCIIGSQPNIHIKNSTFCMTAYPNLTLVNFTS-------H 354

  Fly   205 V-EGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFT 268
            . :.|.|.:.|||...:|::  |.||...|.|:|.:|:||.:.:.|.|.||.|||.:|||||:||
 Frog   355 ANKSFVSGSEEYFKYNMLKI--SAGIEYPGEIRWPLAICLFLAWTIVYASLAKGIKSSGKVVYFT 417

  Fly   269 ALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYAS 333
            |.|||.||:||||||:||||:..||.:::.|.:..:..|.||.|||||:||||...:|.|:..:|
 Frog   418 ATFPYVVLVILLIRGVTLPGAGDGIWWFIMPKWEKLMDAMVWKDAATQIFFSLSAAWGGLITLSS 482

  Fly   334 YNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIA 398
            |||:|||||:|.|:.:..|||||..||||||||:|:|||.|.|.||.||.:|||:.|||||.|:.
 Frog   483 YNKFHNNVYRDTLIVTCTNSATSIFAGFVIFSVIGFMAHILNVDIEKVADQGPGIAFVVYPEALT 547

  Fly   399 TMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKR-NRELFVAGLFSLYFVVGLAS 462
            .:|.|.|||:|||:||||||||:.|...|.|:|::||||||:.| ::.||.......:|::|...
 Frog   548 RLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSVSDEFPKLLRPHKPLFTLICCVAFFIMGFPM 612

  Fly   463 CTQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVA 527
            .||||.|...|:|.|||.||:::...||.:.:|::||..||.|||..||||.|.|:|:|||.||.
 Frog   613 ITQGGIYMLQLVDNYAASYSLVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPSRFWKVCWAFVT 677

  Fly   528 PIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTI 592
            |..|.||..:....:||:||..|.||:|:..:||.:...||:.||.:.:.|:...||:..:|..:
 Frog   678 PTILTFILCFSFYQWEPMTYGSYHYPTWSMVMGWLMLACSVIWIPVMFVIKMYLAPGTFIERLKL 742

  Fly   593 LTTPWRD 599
            :.:|..|
 Frog   743 VCSPQPD 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	268/578 (46%)
slc6a5	XP_031756248.1	SLC6sbd_GlyT2	183..779	CDD:271389	270/582 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010