Protein Alignment DAT and slc6a6

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_017949178.2
• Gene: slc6a6 / 100494063
• XenbaseID: XB-GENE-991256
• Length: 616
• Species: Xenopus tropicalis
• Alignment Length: 615
• Identity: 269/615 - (43%)
• Similarity: 387/615 - (62%)
• Gaps: 46/615 - (7%)

  Fly     8 SKSKTP-TPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGI 71
            |..|:| |..:::.:....:||.|:.|:||:|||.|..:.|.||||||||||||||||||:||.|
 Frog    21 SPGKSPGTRPEDEADGKPPQREKWASKIDFVLSVAGGFIGLGNVWRFPYLCYKNGGGAFLIPYFI 85

  Fly    72 MLVVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFF 136
            .|..||:|:|::|:.|||...:|.||||.::.|:|.|||||.::|...::.||.||:||.:.:.|
 Frog    86 FLFGGGLPVFFLEVVLGQFTSEGGITCWEKICPVFTGIGYASIVIVSLLNVYYIVILAWGVYYLF 150

  Fly   137 ASFTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSA 201
            .||...|||..|:..|||.:|            |...:...:.|          :|:.:|.:
 Frog   151 QSFQGQLPWALCHQPWNTESC------------VEDTFRKNWTM----------WMSMNSTN--- 190

  Fly   202 VGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVW 266
                  |.|..:|::...:|.|  |:||.|:|.:|||:|||||:.::||:|.:|||:.::||||:
 Frog   191 ------FTSPVTEFWEHKVLSL--SKGIDDVGVLKWDLALCLLLTWVICFFCIWKGVRSTGKVVY 247

  Fly   267 FTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAY 331
            |||.||:.:||:|||||:||||:..||::||.|:.:.:...:||:||.||:|||.....|.:.:.
 Frog   248 FTATFPFIMLLVLLIRGVTLPGAAEGIKFYLYPDITRLADPQVWIDAGTQIFFSYAICLGAMTSL 312

  Fly   332 ASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAA 396
            .|||||..|.|:|.:|...:||.|||::||.||||||:||...||.|.|||..||||.|:.||.|
 Frog   313 GSYNKYKYNCYRDCMLLGCLNSGTSFVSGFAIFSVLGFMAQEQGVDIADVAESGPGLAFIAYPKA 377

  Fly   397 IATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLYFVV 458
            ::.||..:|||::||:|||.|||||.|...|..||:|.|.:|...|   .||:|:|.:..|.:::
 Frog   378 VSMMPLPSFWAILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAVVCFLSYLL 442

  Fly   459 GLASCTQGGFYFFHLLDRYAA-GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVC 522
            ||...|:||.|.|.|.|.||| |..:|...|||.:||:|:||.::|.::|.||||:.||.:.:..
 Frog   443 GLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECVAVAWVYGADKFYDNIEDMIGYKPGPWMKWS 507

  Fly   523 WRFVAPIFLLFITVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSL 586
            |..:.|:..:...::.|..|.||||.. ||||.||..|||.:|.||::.||.|.:|.::.:.|||
 Frog   508 WTVITPLLCVACFIFSLAKYTPLTYNKYYVYPDWAIGLGWVLALSSMICIPLVVVFHIVRSDGSL 572

  Fly   587 RQRFTILTTP-----W-RDQQSMAMV-LNG 609
            .:|...:|.|     | :|.::.|.: .||
 Frog   573 IERIKAVTAPREVNRWAKDSEAAAPICTNG 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	260/579 (45%)
slc6a6	XP_017949178.2	SLC6sbd_TauT	41..582	CDD:271398	259/573 (45%)