DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and slc6a4

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	XP_017946918.1	Gene:	slc6a4 / 100493853	XenbaseID:	XB-GENE-22062972	Length:	664	Species:	Xenopus tropicalis

Alignment Length:	587	Identity:	308/587 - (52%)
Similarity:	402/587 - (68%)	Gaps:	41/587 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            ||||||.|:||||||||:||||.|||||||:||:|||||||:||.||.|.|||||||||||:||:
Frog   112 ERETWSKKIDFLLSVIGYAVDLGNVWRFPYVCYQNGGGAFLIPYVIMAVFGGIPLFYMELAMGQY 176

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            :|.|.|:.|.::.|||||||||:.:||.||.||||.|:||:|.:...||.:.||||||.|.|||.
Frog   177 HRNGCISIWRKICPLFKGIGYAICMIALYVAFYYNTIMAWALYYLIFSFRSELPWTSCLNEWNTG 241

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYI 220
            ||.              ||                      ...|:||......|.|.|::.|.:
Frog   242 NCT--------------NY----------------------FQNSSVGWSNSSISPAEEFYTRLV 270

  Fly   221 LELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLT 285
            |::::|:|:||||.|.|.:.||||:::.:.|||:|||:.|||||||.||.|||.||.:|||||.|
Frog   271 LQIHKSKGLHDLGGISWQLTLCLLLIFTVVYFSIWKGVKTSGKVVWVTATFPYIVLALLLIRGAT 335

  Fly   286 LPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSF 350
            |||::.|:.:||.|::..:....||||||.|:|||||||||||||:|||||:|||.|:|||:||.
Frog   336 LPGAWRGVLFYLQPDWEKLLTTAVWVDAAAQIFFSLGPGFGVLLAFASYNKFHNNCYQDALITST 400

  Fly   351 INSATSFIAGFVIFSVLGYMAHTLGVRIEDVATE-GPGLVFVVYPAAIATMPASTFWALIFFMML 414
            :|..|||::|.|||:||||||....:.:.:||.: ||.|:|:.|..|||.||||||:|:|||:||
Frog   401 VNCMTSFMSGLVIFTVLGYMAEMRNLDVSEVAKDTGPSLLFITYAEAIANMPASTFFAIIFFLML 465

  Fly   415 LTLGLDSSFGGSEAIITALSDEFPKI-KRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYA 478
            :||||||:|.|.|.:|||:.||||.| .:.|||||..|.|:.|:..|::.|.||.|...|.:.||
Frog   466 ITLGLDSTFAGLEGVITAVLDEFPHIWGKRRELFVFLLISVCFLGALSTLTFGGAYMVKLFEEYA 530

  Fly   479 AGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYE 543
            .|.::|..||.|||||||.||.|:|..|:|:|:||.||.:|::||..:.|:|||||....:....
Frog   531 TGPAVLTVVFLEAIAVSWFYGINQFCRDVREMLGFSPGWFWKICWVAICPLFLLFIICSFMSSPP 595

  Fly   544 PLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQSMAMVLN 608
            .|...:|.||||...||:||..||.:.:||..::.|.|||||:::||....||   :.|..:.|.
Frog   596 DLRLFNYQYPSWTVVLGYCIGTSSFICVPAYMVYLLTSTPGSIKERFLKSITP---EVSREIPLG 657

  Fly   609 GV 610
            |:
Frog   658 GI 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	303/571 (53%)
slc6a4	XP_017946918.1	5HT_transport_N	48..91	CDD:367522
slc6a4	XP_017946918.1	SLC5-6-like_sbd	113..649	CDD:382020	304/574 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010