Protein Alignment DAT and slc6a4

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_017946918.1
• Gene: slc6a4 / 100493853
• XenbaseID: XB-GENE-22062972
• Length: 664
• Species: Xenopus tropicalis
• Alignment Length: 587
• Identity: 308/587 - (52%)
• Similarity: 402/587 - (68%)
• Gaps: 41/587 - (6%)

  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            ||||||.|:||||||||:||||.|||||||:||:|||||||:||.||.|.|||||||||||:||:
 Frog   112 ERETWSKKIDFLLSVIGYAVDLGNVWRFPYVCYQNGGGAFLIPYVIMAVFGGIPLFYMELAMGQY 176

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            :|.|.|:.|.::.|||||||||:.:||.||.||||.|:||:|.:...||.:.||||||.|.|||.
 Frog   177 HRNGCISIWRKICPLFKGIGYAICMIALYVAFYYNTIMAWALYYLIFSFRSELPWTSCLNEWNTG 241

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYI 220
            ||.              ||                      ...|:||......|.|.|::.|.:
 Frog   242 NCT--------------NY----------------------FQNSSVGWSNSSISPAEEFYTRLV 270

  Fly   221 LELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLT 285
            |::::|:|:||||.|.|.:.||||:::.:.|||:|||:.|||||||.||.|||.||.:|||||.|
 Frog   271 LQIHKSKGLHDLGGISWQLTLCLLLIFTVVYFSIWKGVKTSGKVVWVTATFPYIVLALLLIRGAT 335

  Fly   286 LPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSF 350
            |||::.|:.:||.|::..:....||||||.|:|||||||||||||:|||||:|||.|:|||:||.
 Frog   336 LPGAWRGVLFYLQPDWEKLLTTAVWVDAAAQIFFSLGPGFGVLLAFASYNKFHNNCYQDALITST 400

  Fly   351 INSATSFIAGFVIFSVLGYMAHTLGVRIEDVATE-GPGLVFVVYPAAIATMPASTFWALIFFMML 414
            :|..|||::|.|||:||||||....:.:.:||.: ||.|:|:.|..|||.||||||:|:|||:||
 Frog   401 VNCMTSFMSGLVIFTVLGYMAEMRNLDVSEVAKDTGPSLLFITYAEAIANMPASTFFAIIFFLML 465

  Fly   415 LTLGLDSSFGGSEAIITALSDEFPKI-KRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYA 478
            :||||||:|.|.|.:|||:.||||.| .:.|||||..|.|:.|:..|::.|.||.|...|.:.||
 Frog   466 ITLGLDSTFAGLEGVITAVLDEFPHIWGKRRELFVFLLISVCFLGALSTLTFGGAYMVKLFEEYA 530

  Fly   479 AGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYE 543
            .|.::|..||.|||||||.||.|:|..|:|:|:||.||.:|::||..:.|:|||||....:....
 Frog   531 TGPAVLTVVFLEAIAVSWFYGINQFCRDVREMLGFSPGWFWKICWVAICPLFLLFIICSFMSSPP 595

  Fly   544 PLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQSMAMVLN 608
            .|...:|.||||...||:||..||.:.:||..::.|.|||||:::||....||   :.|..:.|.
 Frog   596 DLRLFNYQYPSWTVVLGYCIGTSSFICVPAYMVYLLTSTPGSIKERFLKSITP---EVSREIPLG 657

  Fly   609 GV 610
            |:
 Frog   658 GI 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	303/571 (53%)
slc6a4	XP_017946918.1	5HT_transport_N	48..91	CDD:397524
		SLC5-6-like_sbd	113..649	CDD:444915	304/574 (53%)