Protein Alignment DAT and slc6a12

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_031754510.1
• Gene: slc6a12 / 100492029
• XenbaseID: XB-GENE-6033368
• Length: 612
• Species: Xenopus tropicalis
• Alignment Length: 580
• Identity: 271/580 - (46%)
• Similarity: 367/580 - (63%)
• Gaps: 42/580 - (7%)

  Fly    25 DERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQ 89
            ::|..||.||:|:|||.|..:.|.|||||||||||||||||.:||.|.|...|||:|::|.||||
 Frog    33 EDRGQWSNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQ 97

  Fly    90 HNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNT 154
            :..:|.||.|.::.|||:|||||..:|..|::.||.||:||:|.:.|:|||..|||.:|||.|||
 Frog    98 YTSQGGITAWRKICPLFEGIGYASQVIEGYLNIYYIVILAWALFYLFSSFTAELPWATCNNTWNT 162

  Fly   155 PNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRY 219
            .:|..|..::.                           |.:||:.|.        |:..|::.|.
 Frog   163 EHCIDFVGKSE---------------------------NFTSLENST--------SSVVEFWERR 192

  Fly   220 ILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGL 284
            :|.|  ||||..||.::||:|||||:.::||||.:|||:.::||||:|||.|||.:|:|||:||:
 Frog   193 VLHL--SEGIEHLGNVRWDLALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYVMLIILLVRGV 255

  Fly   285 TLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTS 349
            ||||::.||.:||.|:.:.:...:||:||.||:|||.....|.|.|..|||||:||.|:|.:...
 Frog   256 TLPGAYEGIIFYLKPDMTRLQDPQVWMDAGTQIFFSYAICQGCLTALGSYNKYNNNCYRDCIALC 320

  Fly   350 FINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMML 414
            |:||.|||:|||.||||||:||...||.|.:||..||||.|:.||.|:..||.|..|:.:||:||
 Frog   321 FLNSITSFVAGFAIFSVLGFMAQEQGVPISEVAESGPGLAFIAYPKAVTMMPVSPLWSCLFFLML 385

  Fly   415 LTLGLDSSFGGSEAIITALSDEFPKI---KRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDR 476
            :.|||||.|...|:::||:.|.||.:   |..||.|:..:..:.:::||...|:||.|.|.|.|.
 Frog   386 IFLGLDSQFVCVESLVTAIVDMFPHVFRKKYRREFFILAVAVICYLLGLILLTEGGMYVFQLFDY 450

  Fly   477 YAA-GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLI 540
            ||| |..:|....||.|.|.::||.|||.::|.||||:.|....:.||.|..|...|...::.||
 Frog   451 YAASGTCLLFVAIFEVICVGYVYGANRFYDNIEDMIGYRPWPLVKYCWLFATPAVCLGTFLFSLI 515

  Fly   541 GYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRD 599
            .|.||.|.: ||||||..|:||.:|.||::.||..|.:.:|.|.||..||...|.||..|
 Frog   516 KYSPLKYNNRYVYPSWGYAIGWLMALSSMICIPIYAFYIILRTKGSFTQRLKQLVTPHTD 575

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	269/574 (47%)
slc6a12	XP_031754510.1	SLC5-6-like_sbd	34..572	CDD:444915	268/574 (47%)