Protein Alignment DAT and slc6a17

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_002933031.1
• Gene: slc6a17 / 100490416
• XenbaseID: XB-GENE-964419
• Length: 725
• Species: Xenopus tropicalis
• Alignment Length: 650
• Identity: 224/650 - (34%)
• Similarity: 336/650 - (51%)
• Gaps: 127/650 - (19%)

  Fly    10 SKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLV 74
            |:...|...:::|..::|..|:.|:.::|:.||::|.|.|||||||||.||||||::|||.|:|:
 Frog    42 SQDSQPKQLEDSSELEDRPAWNNKLQYILAQIGYSVGLGNVWRFPYLCQKNGGGAYMVPYLILLI 106

  Fly    75 VGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASF 139
            :.|||||::|||:||..|:|:|..|..:.|...|||||..::.|:|..||||||.||:.:||.||
 Frog   107 IIGIPLFFLELAVGQRIRRGSIGVWNYICPRLGGIGYASCVVCFFVGLYYNVIIGWSIFYFFQSF 171

  Fly   140 TNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGH 204
            ...|||..|                                        .|..|||    ..|..
 Frog   172 QYPLPWNEC----------------------------------------PTVKNGS----VNVVE 192

  Fly   205 VEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTA 269
            .|..:|:|:.:| .|...|:.|..|.:.|.:.|.|.||||:.:.:...::.|||.:||||::|::
 Frog   193 AECDKSSATTFF-WYREALDISNSISEGGGLNWKMTLCLLVAWTMVCMAMIKGIQSSGKVMYFSS 256

  Fly   270 LFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASY 334
            ||||.||:..|||||.|.||..||.:.|||....:...:||.:|||||||:||.|||.::|::||
 Frog   257 LFPYVVLICFLIRGLFLRGSVDGILHMLTPKVEKMLDPQVWREAATQVFFALGLGFGGVIAFSSY 321

  Fly   335 NKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVR---------------------- 377
            ||..||...||.|.||||..||.:|..|:|:|||:.|:.:..:
 Frog   322 NKQDNNCQFDAALVSFINFFTSVLATLVVFAVLGFKANVMNEKCVVQNAEKILGYINTHDIDYSL 386

  Fly   378 ---------------------------------------IE---DVATEGPGLVFVVYPAAIATM 400
                                                   :|   |.|.:|.||.|:.:..|:...
 Frog   387 IPPHVNFSHLTTEDYAKMYQVIKTVKEDHFQDLHLDACVLEDELDKAVQGTGLAFIAFTEAMTHF 451

  Fly   401 PASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQ 465
            |||.||:::||.||:.|||.|..|....|||.:.|.|   |..:|:.......:.|::||....:
 Frog   452 PASPFWSVMFFFMLINLGLGSMIGTMSGIITPIIDTF---KVRKEILTVSCCIVAFLLGLIFVQR 513

  Fly   466 GGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIF 530
            .|.||.::.|.|:|...:.:.|..|.|||:|:|||.:|.:::.:|:||.|..|:...|::|:|||
 Frog   514 SGNYFVNMFDDYSATLPLTIVVILENIAVAWVYGTKKFMQELTEMLGFRPYSYYFYSWKYVSPIF 578

  Fly   531 LLFITVYGLI--GYEPLTYADYV----------YPSWANALGWCIAGSSVVMIPAVAI---FKLL 580
            :..:....:|  |..|..|:.::          ||:||.:|...:...:::.:|.:.|   |:|:
 Frog   579 MAILLTASVIQLGISPPGYSAWIRELAAEQFVLYPTWALSLLITLIILAILPVPVIFILWQFQLI 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	221/632 (35%)
slc6a17	XP_002933031.1	SLC6sbd_NTT4	59..647	CDD:271403	221/632 (35%)