Protein Alignment DAT and slc6a2

DIOPT Version :9

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_017948962.2
• Gene: slc6a2 / 100486589
• XenbaseID: XB-GENE-486549
• Length: 624
• Species: Xenopus tropicalis
• Alignment Length: 579
• Identity: 316/579 - (54%)
• Similarity: 407/579 - (70%)
• Gaps: 31/579 - (5%)

  Fly    26 ERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFYMELALGQH 90
            |||.|..|:||||||:||:||||||||||:|||||||||||:||.:.|::.|:|||||||||||:
 Frog    62 EREQWGKKIDFLLSVVGFSVDLANVWRFPFLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQY 126

  Fly    91 NRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTSCNNIWNTP 155
            ||:||.|.| ::.|||||:||.|:|||.||.|||||||||||.:..:|||:.|||..|.|.||:.
 Frog   127 NREGAATVW-KICPLFKGVGYTVILIALYVGFYYNVIIAWSLYYLVSSFTSELPWIKCGNEWNSL 190

  Fly   156 NCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAASEYFNRYI 220
            ||..         |::.|.|        .:.||..|   |...|          :.|:|::.|.:
 Frog   191 NCTD---------PMLLNMS--------MISYNTKY---SKFKT----------TPAAEFYERGV 225

  Fly   221 LELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLLILLIRGLT 285
            |.|:.|.||||||..:|.:.:||::|.::.:||||||:.|||||||.||..||.||.:|||||:|
 Frog   226 LHLHESNGIHDLGQPRWQLTICLIVVLIVLFFSLWKGVKTSGKVVWITATLPYVVLFVLLIRGIT 290

  Fly   286 LPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVYKDALLTSF 350
            ||||..||..||..:...:..|.||:|||||:|:|||.|||||:|:|||||:.||.|:|||:||.
 Frog   291 LPGSSKGISAYLHIDIKRLTDASVWIDAATQIFYSLGAGFGVLIAFASYNKFDNNCYRDALMTST 355

  Fly   351 INSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLL 415
            ||..||||:||.|||:||||||...|.||||||||.||||::||.||:|:..|||||::||:|||
 Frog   356 INCVTSFISGFAIFSILGYMAHKHNVNIEDVATEGAGLVFIIYPEAISTLAGSTFWAVVFFIMLL 420

  Fly   416 TLGLDSSFGGSEAIITALSDEFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAAG 480
            |||:||:.||.||:||.|:|:...:||:|:||...:..:.|:..|...|.||.|...|||.:|||
 Frog   421 TLGIDSAMGGMEAVITGLADDISILKRHRKLFTLLVAFITFIFALLCITNGGIYVLTLLDTFAAG 485

  Fly   481 YSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEPL 545
            .|||.||..|||.|||.||.:||||||..|:||.||.||::||:||:|.||||:.:..::.|:||
 Frog   486 TSILFAVLIEAIGVSWFYGVDRFSEDIHRMLGFRPGLYWRLCWKFVSPAFLLFVVIVSIVTYKPL 550

  Fly   546 TYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRFTILTTPWRDQQSMA 604
            .|.:|.:|.|||..||.||.||:.::|...|:|.|:..||||:|.....||..:...:|
 Frog   551 MYDEYKFPPWANRTGWAIALSSMTLVPIYIIYKFLTMRGSLRERLAYCITPENEHHLVA 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	313/569 (55%)
slc6a2	XP_017948962.2	SLC5-6-like_sbd	63..622	CDD:382020	315/578 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	644	1.000	Domainoid score	I163
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H816
Inparanoid	1	1.050	660	1.000	Inparanoid score	I764
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	1	1.000	-	-		FOG0000975
OrthoInspector	1	1.000	-	-		otm48986
Panther	1	1.100	-	-	LDO	PTHR11616
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X639
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160