DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DAT and slc6a14

DIOPT Version :9

Sequence 1:	NP_001261026.1	Gene:	DAT / 36849	FlyBaseID:	FBgn0034136	Length:	644	Species:	Drosophila melanogaster
Sequence 2:	NP_001313379.1	Gene:	slc6a14 / 100150665	ZFINID:	ZDB-GENE-130411-2	Length:	614	Species:	Danio rerio

Alignment Length:	594	Identity:	246/594 - (41%)
Similarity:	356/594 - (59%)	Gaps:	61/594 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFY 82
            ||.||   :|..||.|.:::||:||:||.|.||||||||.||:||||||:||.|||.|.|:|||:
Zfish    36 NDENS---DRGNWSSKREYMLSMIGYAVGLGNVWRFPYLAYKHGGGAFLIPYTIMLAVSGLPLFF 97

  Fly    83 MELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWT- 146
            ||.:.||...:|.|..| :.||:.:|:|..::|::.:|..|||||||:|:.:.||||.:.|||:
Zfish    98 MESSFGQFCSQGPINVW-KAVPILQGVGITMMLVSTFVAIYYNVIIAYSIYYLFASFQDPLPWSI 161

  Fly   147 -SCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAV----GHVE 206
             :||.                                          ..|::.|:||    |.:.
Zfish   162 KNCNT------------------------------------------TASNISTAAVNVSCGQIS 184

  Fly   207 GFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALF 271
            | ||.:.:|::.  :.|.||..:.:.|.:.|.:|||||:.:::...:|:|||.:|||||:|||.|
Zfish   185 G-QSLSEKYWDE--VALQRSSSMDETGPVVWHLALCLLLSWILVGAALFKGIKSSGKVVYFTATF 246

  Fly   272 PYAVLLILLIRGLTLPGSFLGIQYYL--TPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASY 334
            ||.|||||||||.||.|:..||::|:  ..|.:.:.:||||.|||||:||||...:|.|:|.:||
Zfish   247 PYIVLLILLIRGATLEGAKDGIEFYIGSQSNLTKLAEAEVWKDAATQIFFSLSIAWGGLMALSSY 311

  Fly   335 NKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIAT 399
            ||::||.|:|:::....|..||..|||.||||||:|||.....:.:||..|..|.|:.||.|::.
Zfish   312 NKFYNNCYQDSIVVCVTNCGTSIFAGFAIFSVLGHMAHVYQRPVSEVADAGFALAFIAYPDALSK 376

  Fly   400 MPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKI-KRNRELFVAGLFSLYFVVGLASC 463
            :|.|..|:::||.||:||||||.|.|.|.|.|.|.|.:|:: |..|.|....:..:.|::||...
Zfish   377 LPISPLWSILFFFMLITLGLDSQFAGIEVISTCLLDAYPEVLKSKRGLVTTAVCIILFLLGLPCV 441

  Fly   464 TQGGFYFFHLLDRYAAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRY---WQVCWRF 525
            |:.|.|:.:|:|.::||:.:|||...|.:.:..:||.|||.:||..|||.....:   |:.||.|
Zfish   442 TRAGIYWVNLIDTFSAGWILLVAGLLEVLGLCILYGGNRFIKDIEMMIGTKSSLFWLWWRACWFF 506

  Fly   526 VAPIFLLFITVYGLIGYEPLTYADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPGSLRQRF 590
            :.|:.|..|.::.|..:...||:...||.|..:|||||...|::.||.||::|:....|.|.||.
Zfish   507 ITPVVLSIILIWSLYTFTSPTYSSVAYPDWGISLGWCITAFSLMWIPIVAVWKVCKARGGLWQRI 571

  Fly   591 TILTTPWRD 599
            ....:|..|
Zfish   572 KSACSPTED 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	240/581 (41%)
slc6a14	NP_001313379.1	SLC6sbd_ATB0	42..612	CDD:271391	242/585 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0733
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D250396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820