Protein Alignment DAT and slc6a11b

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_073772263.1
• Gene: slc6a11b / 100150472
• ZFINID: ZDB-GENE-121116-2
• Length: 617
• Species: Danio rerio
• Alignment Length: 636
• Identity: 278/636 - (43%)
• Similarity: 385/636 - (60%)
• Gaps: 59/636 - (9%)

  Fly     9 KSKTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIML 73
            :|..|:...:::..:.:||..|:.||:|:|||.|..:.|.|||||||||||||||||.|||.|..
Zfish    21 ESANPSVVRSNDKKVVNERGQWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFVPYVIFF 85

  Fly    74 VVGGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFAS 138
            |..|||:|::|.||||...:|.||||.::.|||:|||||..:|..:::.||.||:||::.:.|..
Zfish    86 VCCGIPVFFLETALGQFTSEGGITCWRKVCPLFEGIGYATQVIEAHLNVYYVVILAWAIFYLFNC 150

  Fly   139 FTNSLPWTSCNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVG 203
            ||..|||.||.:.|||.||..|.:::      |.|:::.|:                   ||.|
Zfish   151 FTTELPWASCGHYWNTENCVDFNNES------IANFTNPYS-------------------TSPV- 189

  Fly   204 HVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFT 268
                     .|::.|.:|::  |.||.::|.::|::||||.|.::||||.:|||..::||||:.|
Zfish   190 ---------MEFWERRVLKI--SSGIEEVGGLRWELALCLAIAWVICYFCIWKGPKSTGKVVYVT 243

  Fly   269 ALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYAS 333
            |.|||.:|||||:||:||||:..||::||.|:.|.:...:|||||.||:|||.....|.|.|..|
Zfish   244 ATFPYFMLLILLLRGITLPGAANGIKFYLYPDISRLSDPQVWVDAGTQIFFSYAICLGCLTALGS 308

  Fly   334 YNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYPAAIA 398
            ||.|:||.|:|.|:...:||.|||:|||.||||||:||:...|.||.||..||||.|:.||.|:.
Zfish   309 YNSYNNNCYRDCLMLCCLNSGTSFVAGFAIFSVLGFMAYEQNVPIEAVAESGPGLAFIAYPKAVT 373

  Fly   399 TMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLYFVVGL 460
            .||.:..||.:|||||:.|||||.|...|:::||:.|.:||..|   .|||.:.|:....|.:||
Zfish   374 MMPWAPLWAALFFMMLIFLGLDSQFVCVESLVTAIVDMYPKTFRVGYRRELLILGMSIASFFLGL 438

  Fly   461 ASCTQGGFYFFHLLDRYAA-GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWR 524
            ...|:||.|.|.|.|.||| |..:|....||:|.:.|:||::||..:|.||||:.|..:.:.||:
Zfish   439 IMLTEGGMYVFQLFDSYAASGMCLLFVAIFESICIGWVYGSDRFYMNIEDMIGYKPIFFIKWCWK 503

  Fly   525 FVAP-----IFLLFITVYGLIGYEPLTYAD-YVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTP 583
            |..|     |||.|     ||.|:||.|.: |.||.|...:||.:|.||:|.||...:|::..|.
Zfish   504 FFTPGICTGIFLFF-----LIKYKPLKYNNVYTYPDWGYGIGWMMAMSSMVCIPLGILFQIWKTK 563

  Fly   584 GSLRQRFTILTTPWRDQQSMAMV-------LNGVTTEVTVVRLTDTETAKE 627
            |:.|:|...||||..|.:....|       :|....::.......|.|.||
Zfish   564 GTFRERIKKLTTPSADLRMRGHVASRGPCAINDADAKMRADGKISTITEKE 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	267/579 (46%)
slc6a11b	XP_073772263.1	None