Protein Alignment DAT and slc6a18

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: NP_001108369.2
• Gene: slc6a18 / 100141332
• ZFINID: ZDB-GENE-080219-9
• Length: 618
• Species: Danio rerio
• Alignment Length: 640
• Identity: 222/640 - (34%)
• Similarity: 310/640 - (48%)
• Gaps: 134/640 - (20%)

  Fly    18 NDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVVGGIPLFY 82
            ::.:|: .||..|..||.:||:.:||||.|.|:|||||||...||||||:||.|.||..|:||.|
Zfish     5 SETSSV-QERPKWDNKVQYLLTCVGFAVGLGNIWRFPYLCQIYGGGAFLIPYLIALVFEGLPLLY 68

  Fly    83 MELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFTNSLPWTS 147
            :|||:||..|||:|..|..:.||..|:|.|.::::|.|..:||.|:||.|.:||.||.:.|||:.
Zfish    69 LELAIGQSLRKGSIGVWHSISPLLGGVGVASMVVSFLVGLFYNTILAWVLWYFFHSFEDPLPWSQ 133

  Fly   148 CNNIWNTPNCRPFESQNASRVPVIGNYSDLYAMGNQSLLYNETYMNGSSLDTSAVGHVEGFQSAA 212
            |                    |:..|..                           |:||...|:.
Zfish   134 C--------------------PINDNLE---------------------------GYVEECVSST 151

  Fly   213 SEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKVVWFTALFPYAVLL 277
            ...:..|...||.|..|...|:::|.:.|||...:.|.|....:||.|.||.|:.||.|||.||.
Zfish   152 PVNYYWYRQTLNISPDIEQSGSLQWTLVLCLATAWSIVYICFIRGIETIGKAVYVTATFPYLVLT 216

  Fly   278 ILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLLAYASYNKYHNNVY 342
            |.|:|.|||||:..|:||..||::|.:...:||:|||||:||||...||.|:|::|||...|:..
Zfish   217 IFLVRALTLPGATDGLQYLFTPDWSLLTNPQVWLDAATQIFFSLSLAFGGLIAFSSYNPKKNDCE 281

  Fly   343 KDALLTSFINSATSFIAGFVIFSVLGYMA------------------------------------ 371
            :|||....||||||..|...||::||:.|
Zfish   282 RDALFVGIINSATSLYASIPIFAILGFKATSNFNSCVNSNILDLTNAFDIGDRNITIENYDSWLR 346

  Fly   372 ----------------HTLGVRIEDVATEGPGLVFVVYPAAIATMPASTFWALIFFMMLLTLGLD 420
                            |.:.....|.:..|.||.|:|:..|:..||.|..||::||:||.:|||.
Zfish   347 DLNASDPDRVSSLNLKHCVLKNFLDQSASGTGLAFIVFTEAVIEMPGSQVWAVLFFVMLFSLGLS 411

  Fly   421 SSFGGSEAIITALSD------EFPKIKRNRELFVAGLFSLYFVVGLASCTQGGFYFFHLLDRYAA 479
            |.||..|.::|.|.|      ..||     |:|...:..:.|:|.|......|.|:..:.:.|..
Zfish   412 SMFGNLEGVLTPLLDLHMVPRWMPK-----EIFTGLICVVNFLVALIFTLGSGNYWLEIFNSYVG 471

  Fly   480 GYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQVCWRFVAPIFLLFITVYGLIGYEP 544
            ...:||..|||.|||...||..|||:||..|.|..|..:|:.||..::|:.||.:    |:.|..
Zfish   472 SVPLLVIAFFEIIAVVCFYGIKRFSDDIEQMTGRRPNLFWRCCWMGISPVMLLVV----LVAYVV 532

  Fly   545 LTYADY-VYPSWANAL------------GW----CIAGSS--VVMIPAVAIFKLL 580
            :....: .||:|....            .|    |:..||  |:.||.||:::|:
Zfish   533 VQVQKHPTYPAWNPQYENFPETEEKPYSTWVFSICVLLSSVPVISIPIVALYRLM 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	220/631 (35%)
slc6a18	NP_001108369.2	None