Protein Alignment DAT and slc6a8l

DIOPT Version :10

• Sequence 1: NP_001261026.1
• Gene: DAT / 36849
• FlyBaseID: FBgn0034136
• Length: 644
• Species: Drosophila melanogaster
• Sequence 2: XP_012815966.1
• Gene: slc6a8l / 100127575
• XenbaseID: XB-GENE-5768780
• Length: 654
• Species: Xenopus tropicalis
• Alignment Length: 635
• Identity: 276/635 - (43%)
• Similarity: 387/635 - (60%)
• Gaps: 61/635 - (9%)

  Fly    11 KTPTPHDNDNNSISDERETWSGKVDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYGIMLVV 75
            |.|.|          |||||:.::||::|.:||||.|.|||||||||||||||.||:||.:::.|
 Frog    55 KIPIP----------ERETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYLLIVFV 109

  Fly    76 GGIPLFYMELALGQHNRKGAITCWGRLVPLFKGIGYAVVLIAFYVDFYYNVIIAWSLRFFFASFT 140
            ||||:|::|:||||..::|.|..| .:.|||||:|:|.::|.|:.:.||.:|:.|.|.:...|||
 Frog   110 GGIPVFFLEIALGQFMKQGGIAAW-NIAPLFKGLGFASMVIVFFCNTYYIMILVWGLYYLVHSFT 173

  Fly   141 NSLPWTSCNNIWNTPNCRPF----ESQNASRVPVIGNYSDLYAMGNQS--LLYNETYMNGSSLDT 199
            |:|||.:|.|.||:..|...    ...|.|    :.|.:|...:.|.|  .|.|:
 Frog   174 NTLPWATCGNPWNSKECTEVFLVDHCNNGS----LANVTDSGTLVNISCDALVNK---------- 224

  Fly   200 SAVGHVEGFQSAASEYFNRYILELNRSEGIHDLGAIKWDMALCLLIVYLICYFSLWKGISTSGKV 264
                     :|...|::.|.:|::  |.|:::.|.:.|.|.|||:..::|.||.:|||:.::|||
 Frog   225 ---------RSPVIEFWERKVLQI--SGGLNEPGQLNWQMILCLMATWVIVYFCIWKGVKSTGKV 278

  Fly   265 VWFTALFPYAVLLILLIRGLTLPGSFLGIQYYLTPNFSAIYKAEVWVDAATQVFFSLGPGFGVLL 329
            |:|||||||.||::||..|:||||:..||.|||.||:|.:.:|:||:||.||:|||...|.|.|.
 Frog   279 VYFTALFPYVVLIVLLAHGVTLPGALDGIVYYLKPNWSKLAEAQVWIDAGTQIFFSYAIGLGALT 343

  Fly   330 AYASYNKYHNNVYKDALLTSFINSATSFIAGFVIFSVLGYMAHTLGVRIEDVATEGPGLVFVVYP 394
            |..|||::|||.|:||.:.:.|||.|||.||||:|||||:||...||.|..||..||||.|:.||
 Frog   344 ALGSYNRFHNNCYRDAYILAAINSTTSFFAGFVVFSVLGFMASEQGVHISKVAESGPGLAFIAYP 408

  Fly   395 AAIATMPASTFWALIFFMMLLTLGLDSSFGGSEAIITALSDEFPKIKR---NRELFVAGLFSLYF 456
            .|:..||.:..||.:||.|||.|||||.|.|.|..||.:.|.||:...   .||:..|....:.|
 Frog   409 KAVTLMPFAPIWAALFFFMLLILGLDSQFVGVEGFITGIMDLFPQPINGFVRREVTAALCCLVCF 473

  Fly   457 VVGLASCTQGGFYFFHLLDRY-AAGYSILVAVFFEAIAVSWIYGTNRFSEDIRDMIGFPPGRYWQ 520
            ::.|:..|:||.|.|.|.|.| |:|.::|...|:|.:.::|:||.:||.:||..|||:.|..|.:
 Frog   474 IIDLSMVTEGGMYVFQLFDYYSASGITLLWQAFWECVVIAWVYGADRFMDDIARMIGYRPLPYMK 538

  Fly   521 VCWRFVAPIFLLFITVYGLIGYEPLTY-ADYVYPSWANALGWCIAGSSVVMIPAVAIFKLLSTPG 584
            .||..:.|:..:.|.|:.::.|:|||| ..||||.|..|:||.:|.:|::.||...:.|:|.:.|
 Frog   539 WCWSVLTPLVCVGIFVFHVVNYKPLTYNKSYVYPWWGEAIGWSLALASMLCIPLTVVCKMLRSKG 603

  Fly   585 SLRQRFTILTTP-WRDQQSMAMVLNGVTTEVTVVRLTDTETAKEPVDVXV 633
            |||:|:.:|||| |....     |..:|.|        .||...|.|..|
 Frog   604 SLRERWHLLTTPVWGHHH-----LEYLTPE--------AETKLLPPDTLV 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DAT	NP_001261026.1	SLC6sbd_SERT-like_u1	27..597	CDD:271405	263/581 (45%)
slc6a8l	XP_012815966.1	SLC6sbd_CT1	61..654	CDD:271397	272/619 (44%)