DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ctnnd2a and p120ctn

DIOPT Version :9

Sequence 1:	XP_002666700.2	Gene:	ctnnd2a / 368485	ZFINID:	ZDB-GENE-030616-60	Length:	1221	Species:	Danio rerio
Sequence 2:	NP_001036444.1	Gene:	p120ctn / 3355143	FlyBaseID:	FBgn0260799	Length:	781	Species:	Drosophila melanogaster

Alignment Length:	815	Identity:	314/815 - (38%)
Similarity:	435/815 - (53%)	Gaps:	152/815 - (18%)

- Green bases have known domain annotations that are detailed below.

Zfish   361 HSSEQYKISHELYATATLQRPGSLAGSRGSYSN--QHAHLGPELRPLQSPEHHIEPIYEDRVYQK 423
            |.:....::||         |.::....||:.|  |.:..|....||    :..:|.....:.:.
  Fly    19 HINMDLSLTHE---------PANMQSQFGSFQNYDQFSAAGYSSTPL----YITKPTGVGAITKV 70

Zfish   424 VPMRSLSQSQGETLPPAHTGTYRNNTAPSSPGVDSVPLQRT-----ASQ-NATGTFPRGGYASGQ 482
            .|  ..||::.||          |:|..|.|.:::.||..|     |.| ..|..:...|...|.
  Fly    71 AP--HCSQNKIET----------NSTDNSIPDIENHPLATTVRYVQAGQYEDTSEYGVAGLTCGI 123

Zfish   483 SANYTDTYRTLPYCSSVESPYS---------KSGPALPPEGNLARSPSIDSIQ----KDPREF-- 532
            .:.|| ....:|||.:.::.|:         |.....|...|:..:.::...|    |...||
  Fly   124 DSEYT-AEAVVPYCYTSDANYTGIQNTTSSIKPFSGRPFNDNINGAEAVADSQCRTFKSSAEFKL 187

Zfish   533 ---------------------------------GWRDPELPEVIQMLQHQFPSVQSNAAAYLQHL 564
                                             .||||.|.|||..|.:...::::|||||||||
  Fly   188 PQFAMSSINTVPQRLEEKDDYIEGSENDICSTMRWRDPNLSEVISFLSNPSSAIKANAAAYLQHL 252

Zfish   565 CFGDNKIKAEIRRQGGIQLLVDLLDHRMAEVHRSACGALRNLVYGKANDDNKIALKNCGGIPALV 629
            |:.|:..|...|..|||..||.||.:...|:|::||||||||.||:.||:||..:||.|||.|||
  Fly   253 CYMDDPNKQRTRSLGGIPPLVRLLSYDSPEIHKNACGALRNLSYGRQNDENKRGIKNAGGIAALV 317

Zfish   630 RLLRKTSDVEVRELVTGVLWNLSSCDALKMPIIQDALAVLTNTVIIPHSTWDVSPHQEDRKLQMH 694
            .||.::.:.||:|||||||||:|||:.||..||.:||..:..:||.|||.||.....|     ..
  Fly   318 HLLCRSQETEVKELVTGVLWNMSSCEDLKRSIIDEALVAVVCSVIKPHSGWDAVCCGE-----TC 377

Zfish   695 TSQVLRNATGCLRNVSSAGEEARRRMRECEGLTDTLLFVIQTSLGSSEIDSKTIENCVCILRNLS 759
            .|.|.|||:|.|||||||||.||..:|.||.|.:.||:|::||:..:.|.:||:|||||||||||
  Fly   378 FSTVFRNASGVLRNVSSAGEHARGCLRNCEHLVECLLYVVRTSIEKNNIGNKTVENCVCILRNLS 442

Zfish   760 YRLAAETSQGQQMGTDELD--GLLCSD---ASGKDGETSGCWGKKKKKKKSQDQWDGVGPLPDTA 819
            ||.       |::.....|  ..:..:   .|...||..||:|..||||::.:. |.:.....:|
  Fly   443 YRC-------QEVDDPNYDKHPFITPERVIPSSSKGENLGCFGTNKKKKEANNS-DALNEYNISA 499

Zfish   820 EPP----------KGIQMLWHPSIVKPYLTLLSECSNPDTLEGAAGALQNLAAGSWKWSVYIRAA 874
            :..          ||.:.||.|.:|:.||:||..||||:|||.||||:|||:|..|:.|:.|||.
  Fly   500 DYSKSSVTYNKLNKGYEQLWQPEVVQYYLSLLQSCSNPETLEAAAGAIQNLSACYWQPSIDIRAT 564

Zfish   875 VRKEKGLPILVELLRIDNDRVVCAVATALRNMALDVRNKELIGKYAMRDLVHRLPGGN-----NA 934
            |||||||||||||||::.|||||||||||||:|:|.|||||||||||||||.:||.||     |.
  Fly   565 VRKEKGLPILVELLRMEVDRVVCAVATALRNLAIDQRNKELIGKYAMRDLVQKLPSGNVQHDQNT 629

Zfish   935 SASSGGTANSTAGKTMCDDTVTAICCALHEVITKNMENAKALRDAGGIEKLIGIARSKGDKHSPK 999
            |                |||:||:...::|||.||.|.:::|.|:|||::|:.|.:.| :|::..
  Fly   630 S----------------DDTITAVLATINEVIKKNPEFSRSLLDSGGIDRLMNITKRK-EKYTSC 677

Zfish  1000 VVKAASQVLSSMWQYRDLRSLYKKDGYSQYHFVGSASTIERDRQRPYSSSRTPSVSPVRTSPN-- 1062
            |:|.|||||.:|||:.:||.:|||:|:.:..||          .:.:::..||.     :|||
  Fly   678 VLKFASQVLYTMWQHNELRDVYKKNGWKEQDFV----------SKHFTAHNTPP-----SSPNNV 727

Zfish  1063 NRSASAPASPREMISLKDRKSEFDSTGTNATYHAN 1097
            |.:.:.|.:.:.....:||..:   .||:..|.||
  Fly   728 NNTLNRPMASQGRTRYEDRTIQ---RGTSTLYSAN 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ctnnd2a	XP_002666700.2	ARM	531..653	CDD:237987	68/156 (44%)
		armadillo repeat	539..564	CDD:293788	12/24 (50%)
		armadillo repeat	572..608	CDD:293788	19/35 (54%)
		armadillo repeat	616..651	CDD:293788	21/34 (62%)
		armadillo repeat	658..709	CDD:293788	21/50 (42%)
		ARM	691..>761	CDD:237987	40/69 (58%)
		armadillo repeat	825..862	CDD:293788	22/36 (61%)
		ARM	826..928	CDD:237987	73/101 (72%)
		armadillo repeat	872..906	CDD:293788	29/33 (88%)
		armadillo repeat	913..967	CDD:293788	26/58 (45%)
		ARM	969..1013	CDD:214547	19/43 (44%)
		armadillo repeat	973..1009	CDD:293788	15/35 (43%)
p120ctn	NP_001036444.1	ARM	227..341	CDD:237987	62/113 (55%)
		armadillo repeat	227..252	CDD:293788	12/24 (50%)
		armadillo repeat	260..296	CDD:293788	19/35 (54%)
		armadillo repeat	304..339	CDD:293788	21/34 (62%)
		ARM	307..442	CDD:237987	76/139 (55%)
		armadillo repeat	347..392	CDD:293788	20/49 (41%)
		armadillo repeat	515..556	CDD:293788	23/40 (58%)
		ARM	516..643	CDD:237987	84/142 (59%)
		armadillo repeat	562..596	CDD:293788	29/33 (88%)
		armadillo repeat	601..641	CDD:293788	26/55 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5526
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55574
Inparanoid	1	1.050	430	1.000	Inparanoid score	I1698
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D125744at33208
OrthoFinder	1	1.000	-	-		FOG0006320
OrthoInspector	1	1.000	-	-		otm24726
orthoMCL	1	0.900	-	-		OOG6_104813
Panther	1	1.100	-	-	O	PTHR10372
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2332
SonicParanoid	1	1.000	-	-		X765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	11.000