DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn2 and Sntg1

DIOPT Version :9

Sequence 1:	NP_788381.1	Gene:	Syn2 / 36848	FlyBaseID:	FBgn0034135	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001277322.1	Gene:	Sntg1 / 71096	MGIID:	1918346	Length:	517	Species:	Mus musculus

Alignment Length:	496	Identity:	197/496 - (39%)
Similarity:	295/496 - (59%)	Gaps:	12/496 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KVRTGMVHVSDGKSRPEPLRLNLTMELLSLQKLEVVTPSSCHPNGPPMESKERMVQITRQKQGGL 89
            :.:||:..:.||...|..:||:|..:||.||:.:|:..|     |.|..|.||.|.|.||..||.
Mouse     9 ETKTGVCLLQDGNQEPFKVRLHLARDLLMLQEQDVLCVS-----GEPFYSGERTVTIRRQTVGGF 68

  Fly    90 GLSIKGGAEHKLPILISRIYKDQAADITGQLFVGDAIIKVNGEYITACPHDDAVNILRNAGDIVV 154
            ||||||||||.:|::||:|.|:|.|:::|.||:||||:::||..:..|.|::.|.:|||||:.|.
Mouse    69 GLSIKGGAEHNIPVVISKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVT 133

  Fly   155 LTVKHYRAATPFLQKQLTKD---TPDSDNDVTCAELKADEGYKSSVN-SGTISRSCSR-PMSICS 214
            |||...:.|..||:..:.:|   .|...:..|.:.| .|.|...:.: :.|.:.|||. |.|...
Mouse   134 LTVSFLKRAPAFLKLPVNEDCACAPSDQSSGTSSPL-CDSGLHLNYHPNNTDTLSCSSWPTSPGL 197

  Fly   215 EPEKRWTDVVAVPLMMAYVTRYIYGTDKLRQNAFEVRGLNGISTGVIHCDELAILSQWLKLITDN 279
            ..||||.|:..:||:.|..::|:.|||..|||||:|..::|:.:|::.|........||:.|..|
Mouse   198 RWEKRWCDLRLIPLLHARFSQYVPGTDLSRQNAFQVVAVDGVCSGILQCLSAEDCMDWLQAIASN 262

  Fly   280 VVGLTHLQMKLYNRNFAVGERIEYMGWVNEGVINNNISWQSYKPRFLLLKGTEVMLFETPPLNVA 344
            :..||...:|..||||.|.::|.||||. |.....::..:.|.|.||.|:|:.:..|.:||:...
Mouse   263 ISNLTKHNIKKINRNFPVNQQIVYMGWC-EAREQESLQDRVYTPVFLALRGSCLYRFLSPPVTTW 326

  Fly   345 GISKALVVYKVYQTMFRIVKESETVDSRQHCFLLQSSGHEPRYLSVETRQELLRIENSWNAAIVT 409
            ..::|...:.|.:.|.:::|:|:.:|.|:|||.:||...|..|.|||...:|.:.|.::..|...
Mouse   327 DWTRAEKTFSVCEIMCKVLKDSDLLDRRKHCFTMQSECGEDLYFSVELESDLAQWERAFQTATFL 391

  Fly   410 SVIKLGRKTFAVSHHGKSGGLTLDWQAGFSLTEGAESATVWQYKFSQLRGSSDDGKSKLKLHFQD 474
            .|.::..||:|........|||:|:..||...:.|..|.:|:||||||:|||||||||:|..||:
Mouse   392 EVERIQCKTYACVLESHLMGLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQN 456

  Fly   475 HDSRAIETKELECQVLQSLLFCMHAFLTAKVASVDPAFLSS 515
            .|::.||.||||...|.::|.|:|:|..||||.:||.||.:
Mouse   457 PDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLFLGN 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn2	NP_788381.1	PDZ_signaling	76..158	CDD:238492	45/81 (56%)
Syn2	NP_788381.1	PH	301..407	CDD:214574	34/105 (32%)
Sntg1	NP_001277322.1	PDZ_signaling	55..136	CDD:238492	44/80 (55%)
		PH	191..264	CDD:214574	27/72 (38%)
		PH	284..389	CDD:214574	34/105 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834112
Domainoid	1	1.000	227	1.000	Domainoid score	I2495
eggNOG	1	0.900	-	-		E1_KOG3549
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56834
Inparanoid	1	1.050	346	1.000	Inparanoid score	I2297
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46473
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003391
OrthoInspector	1	1.000	-	-		otm42643
orthoMCL	1	0.900	-	-		OOG6_106123
Panther	1	1.100	-	-	O	PTHR10554
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4001
SonicParanoid	1	1.000	-	-		X2288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790