Protein Alignment Syn2 and SNTG2

DIOPT Version :9

• Sequence 1: NP_788381.1
• Gene: Syn2 / 36848
• FlyBaseID: FBgn0034135
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_016859850.1
• Gene: SNTG2 / 54221
• HGNCID: 13741
• Length: 540
• Species: Homo sapiens
• Alignment Length: 493
• Identity: 192/493 - (38%)
• Similarity: 294/493 - (59%)
• Gaps: 27/493 - (5%)

  Fly    43 LRLNLTMELLSLQKLEVVTPSSCHPNGPPMESKERMVQITRQKQGGLGLSIKGGAEHKLPILISR 107
            :||.||.|:|::||.:||.....|..     ...|.|.:.||..||||||||||:||.:|::||:
Human    44 IRLKLTKEVLTIQKQDVVCVGGSHQG-----RNRRTVTLRRQPVGGLGLSIKGGSEHNVPVVISK 103

  Fly   108 IYKDQAADITGQLFVGDAIIKVNGEYITACPHDDAVNILRNAGDIVVLTVKHYRAATPFLQKQLT 172
            |::|||||.||.||||||:::|||.::....|::.|::||||||.|.:||::.|.|..||:..|.
Human   104 IFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLRNAGDEVTITVEYLREAPAFLKLPLG 168

  Fly   173 KDTPDSDNDVTCAELKADEGYKSSVNSGTISRSCSRPMSICSEP--EKRWTDVVAVPLMMAYVTR 235
            ...|.||:....:....|.|...:.||.|.:.| |....|..:|  ||||.|.::|||.||.::|
Human   169 SPGPSSDHSSGASSPLFDSGLHLNGNSSTTAPS-SPSSPIAKDPRYEKRWLDTLSVPLSMARISR 232

  Fly   236 YIYGTDKLRQNAFEVRGLNGISTGVIHCDELAILSQWLKLITDNVVGLTHLQMKLYNRNFAVGER 300
            |..||:|||.|||||..|:|:|:|::........:.||:.::.|:..||...||:.|:..:..::
Human   233 YKAGTEKLRWNAFEVLALDGVSSGILRFYTAQDGTDWLRAVSANIRELTLQNMKMANKCCSPSDQ 297

  Fly   301 IEYMGWVNEGVINNNISWQSYKPRFLLLKGTEVMLFETPPLNVAGISKALVVYKVYQTMFRI--- 362
            :.:||||||.:...:.| |:::|:||.|||....:|.|||::.....:|...|.:.:.:|::
Human   298 VVHMGWVNEKLQGADSS-QTFRPKFLALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKF 361

  Fly   363 ---------------VKESETVDSRQHCFLLQSSGHEPRYLSVETRQELLRIENSWNAAIVTSVI 412
                           :::.:..|.|.:||.:.:...:....:||...||...|.|:..|....|.
Human   362 WLTEDCWLQANLYLGLQDFDFEDQRPYCFSIVAGHGKSHVFNVELGSELAMWEKSFQRATFMEVQ 426

  Fly   413 KLGRKTFAVSHHGKSGGLTLDWQAGFSLTEGAESATVWQYKFSQLRGSSDDGKSKLKLHFQDHDS 477
            :.|.:|:..|..|:....|:|:..||:..|......:|::|||||:|||||||:::||.||:.|:
Human   427 RTGSRTYMCSWQGEMLCFTVDFALGFTCFESKTKNVLWRFKFSQLKGSSDDGKTRVKLLFQNLDT 491

  Fly   478 RAIETKELECQVLQSLLFCMHAFLTAKVASVDPAFLSS 515
            :.|||||||.|.|:::|.|:|:|:.||||||||.|:.|
Human   492 KQIETKELEFQDLRAVLHCIHSFIAAKVASVDPGFMDS 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn2	NP_788381.1	PDZ_signaling	76..158	CDD:238492	46/81 (57%)
		PH	301..407	CDD:214574	31/123 (25%)
SNTG2	XP_016859850.1	PDZ_signaling	73..154	CDD:238492	46/80 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143877
Domainoid	1	1.000	235	1.000	Domainoid score	I2371
eggNOG	1	0.900	-	-		E1_KOG3549
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	353	1.000	Inparanoid score	I2256
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46473
OrthoDB	1	1.010	-	-		D1103724at2759
OrthoFinder	1	1.000	-	-		FOG0003391
OrthoInspector	1	1.000	-	-		otm40572
orthoMCL	1	0.900	-	-		OOG6_106123
Panther	1	1.100	-	-	LDO	PTHR10554
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4001
SonicParanoid	1	1.000	-	-		X2288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800