DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn2 and Sntg1

DIOPT Version :9

Sequence 1:	NP_788381.1	Gene:	Syn2 / 36848	FlyBaseID:	FBgn0034135	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001178910.1	Gene:	Sntg1 / 500394	RGDID:	1560290	Length:	519	Species:	Rattus norvegicus

Alignment Length:	504	Identity:	188/504 - (37%)
Similarity:	286/504 - (56%)	Gaps:	27/504 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KVRTGMVHVSDGKSRPEPLRLNLTMELLSLQKLEVVTPSSCHPNGPPMESKERMVQITRQKQG-G 88
            :.:||:..:.||...|..:||:|..:||.||:.:|:..|     |.|..|..|:|:|..|..| .
  Rat     9 ETKTGVCLLQDGNQEPFKVRLHLARDLLMLQEQDVLCVS-----GEPFYSGVRLVKIFSQSVGCR 68

  Fly    89 LGLSIKGGAEHKLPILISRIYKDQAADITGQLFVGDAIIKVNGEYITACPHDDAVNILRNAGDIV 153
            .||||.||..|.:|:...::.|.|.::::|.||:||||:::||..:..|.|::.|.:|||||:.|
  Rat    69 FGLSILGGLTHSVPVFAGKLSKSQDSELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEV 133

  Fly   154 VLTVKHYRAATPFLQKQLTKD---TPDSDNDVTCAELKADEGYKSSVN-SGTISRSCSR-PMSIC 213
            .|||...:.|..||:..|.:|   .|...:..|.:.| .|.|...:.: :.|.:.|||. |.|..
  Rat   134 TLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPL-CDSGLHLNYHPNNTDTLSCSSWPTSPG 197

  Fly   214 SEPEKRWTDVVAVPLMMAYVTRYIYGTDKLRQNAFEVRGLNGISTGVIHCDELAILSQWLKLITD 278
            ...||||.|:..:||:.|..::|:.|||..|||||:|..::|:.:|::.|........||:.|..
  Rat   198 LRWEKRWCDLRLIPLLHARFSQYVPGTDLSRQNAFQVVAVDGVCSGILQCLSAEDCMDWLQAIAT 262

  Fly   279 NVVGLTHLQMKLYNRNFAVGERIEYMGWVNEGVINNNISWQS-------YKPRFLLLKGTEVMLF 336
            |:..||...:|..||||.|.::|.||||..        :|:.       |.|.||.|:|:.:..|
  Rat   263 NISNLTKHNIKKINRNFPVNQQIVYMGWCE--------AWEQESLQDRVYTPVFLALRGSCLYRF 319

  Fly   337 ETPPLNVAGISKALVVYKVYQTMFRIVKESETVDSRQHCFLLQSSGHEPRYLSVETRQELLRIEN 401
            .:||:.....::|...:.|.:.|.:::|:|:.:|.|:|||.:||...|..|.|||...:|.:.|.
  Rat   320 LSPPVTTWDWTRAEKTFSVCEIMCKVLKDSDLLDRRKHCFTMQSECGEDLYFSVELESDLAQWER 384

  Fly   402 SWNAAIVTSVIKLGRKTFAVSHHGKSGGLTLDWQAGFSLTEGAESATVWQYKFSQLRGSSDDGKS 466
            ::..|....|.::..||:|........|||:|:..||...:.|..|.:|:||||||:||||||||
  Rat   385 AFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSDDGKS 449

  Fly   467 KLKLHFQDHDSRAIETKELECQVLQSLLFCMHAFLTAKVASVDPAFLSS 515
            |:|..||:.|::.||.||||...|.::|.|:|:|..||||.:||.||.:
  Rat   450 KIKFLFQNQDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPLFLGN 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn2	NP_788381.1	PDZ_signaling	76..158	CDD:238492	35/82 (43%)
Syn2	NP_788381.1	PH	301..407	CDD:214574	34/112 (30%)
Sntg1	NP_001178910.1	PDZ_signaling	55..137	CDD:238492	34/81 (42%)
		PH	192..260	CDD:214574	25/67 (37%)
		PH	197..260	CDD:278594	23/62 (37%)
		PH	285..390	CDD:214574	34/112 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337658
Domainoid	1	1.000	234	1.000	Domainoid score	I2307
eggNOG	1	0.900	-	-		E1_KOG3549
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56834
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2805
OMA	1	1.010	-	-		QHG46473
OrthoDB	1	1.010	-	-		D1103724at2759
OrthoFinder	1	1.000	-	-		FOG0003391
OrthoInspector	1	1.000	-	-		otm44710
orthoMCL	1	0.900	-	-		OOG6_106123
Panther	1	1.100	-	-	O	PTHR10554
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2288
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.810