Protein Alignment Syn2 and stn-2

DIOPT Version :10

• Sequence 1: NP_788381.1
• Gene: Syn2 / 36848
• FlyBaseID: FBgn0034135
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001024610.1
• Gene: stn-2 / 181029
• WormBaseID: WBGene00017866
• Length: 515
• Species: Caenorhabditis elegans
• Alignment Length: 518
• Identity: 181/518 - (34%)
• Similarity: 291/518 - (56%)
• Gaps: 37/518 - (7%)

  Fly    19 KLDQNLK-VRTGMVHVSDGKSRPEPLRLNLTMELLSLQKLEVVTPSSCHPNGPPMESKE------ 76
            |...||. |..|:|.:|||.:.....||.|:.:.|.:|.::..|       ..|.|:||
 Worm     5 KSHHNLDVVHHGIVLISDGNATSRSSRLLLSKDELCIQVIDDGT-------AEPEEAKETFLENA 62

  Fly    77 -RMVQITRQKQGGLGLSIKGGAEH--KLPILISRIYKDQAADITGQLFVGDAIIKVNGEYITACP 138
             |.|.|.::...|.|||||||:|:  .:||:||:|:|...||..|:||:||||::|||..|....
 Worm    63 TRQVVIVKKPDSGFGLSIKGGSENAQNMPIVISKIFKGLPADECGELFIGDAIVEVNGISIEGQS 127

  Fly   139 HDDAVNILRNAGDIVVLTVKHYRAATPFLQKQLTKDTPDSDNDVTCAELKADEGYKSSVNSGTIS 203
            ||:.||:|:::||.|.|.|:|:...||||     |.......|.|..:|......:|........
 Worm   128 HDEVVNMLKSSGDQVTLGVRHFTHMTPFL-----KPAQSLQPDGTLDQLFDGRSTRSHKAQSESR 187

  Fly   204 RSCSRPMSICSEPEKRWTDVVAVPLMMAYVTRYIYGTDKLRQNAFEVRGLNGISTGVIHCDELAI 268
            .|.|:........||:|..:.::||.|||||||::|||.:|.|:||||.::|.|:|::||::.:.
 Worm   188 LSDSKWQQHIDGREKKWKTLTSLPLAMAYVTRYLWGTDNIRTNSFEVRAVDGRSSGIVHCEDTSA 252

  Fly   269 LSQWLKLITDNVVGLTHLQMKLYNRNFAVGERIEYMGWVNEGVINNN------ISWQSYKPRFLL 327
            |.||:..|:.:::.|....:|:.|:.....|:|.|:||||| .:|::      |.||   ||||:
 Worm   253 LEQWISHISKHILSLNQKSIKMSNKYLHQSEQISYIGWVNE-YLNDDDQEELKIRWQ---PRFLI 313

  Fly   328 LKGTEVMLFETPPLNVAGISKALVVYKVYQTMFR-IVKESETVDSRQHCFLLQSSGHEP-RYLSV 390
            |||::|..|:.||||...::|.:.:||.|....: :...|...|.|.:|||:::....| .|||.
 Worm   314 LKGSDVCFFDVPPLNSEDLNKCVYLYKCYDVAVKQVPNSSPRRDKRDNCFLIETPLQVPNHYLSF 378

  Fly   391 ETRQELLRIENSWNAAIVTSVIKLGRKTFAVSHHGKSGGLTLDWQAGFSLTEGAESATVWQYKFS 455
            |........|.::...:..::.::..:|||.:..|::.|:..|.:.|.||.:....:.:|||:|.
 Worm   379 EAVSAFELFEQAYYRTVYNTISQMQSRTFACNFEGRASGIVFDIKQGISLYDIPTKSYIWQYRFR 443

  Fly   456 QLRGSSDDGKSKLKLHFQDH---DSRAIETKELECQVLQSLLFCMHAFLTAKVASVDPAFLSS 515
            .|:..:||||..::|.|.|.   :|..||.|::||:.:.:::|.:|:|:.|::.|.||.:|.:
 Worm   444 DLQAVADDGKLCVQLSFNDDRSLNSDRIEVKDIECEDVVTVVFNLHSFVLARIVSTDPDYLKA 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Syn2	NP_788381.1	PDZ_syntrophin-like	77..159	CDD:467262	41/83 (49%)
		PH	301..407	CDD:214574	40/113 (35%)
stn-2	NP_001024610.1	PDZ_syntrophin-like	64..148	CDD:467262	41/83 (49%)
		PH_17	204..261	CDD:465616	27/56 (48%)
		PH	289..386	CDD:459697	37/100 (37%)