DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Syn2 and sntg1

DIOPT Version :9

Sequence 1:	NP_788381.1	Gene:	Syn2 / 36848	FlyBaseID:	FBgn0034135	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_004915254.1	Gene:	sntg1 / 100489155	XenbaseID:	XB-GENE-1011498	Length:	522	Species:	Xenopus tropicalis

Alignment Length:	500	Identity:	198/500 - (39%)
Similarity:	302/500 - (60%)	Gaps:	20/500 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KVRTGMVHVSDGKSRPEPLRLNLTMELLSLQKLEVVTPSSCHPNGPPMESKERMVQITRQKQGGL 89
            :.:||:..:.||...|..:||:|..::|.:|:.:|:..|     |.|..|.||.|.|.||..||.
Frog     9 EAKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVS-----GEPFYSGERTVAIRRQTVGGF 68

  Fly    90 GLSIKGGAEHKLPILISRIYKDQAADITGQLFVGDAIIKVNGEYITACPHDDAVNILRNAGDIVV 154
            |||||||:||.:|::||:|.|:|.|:::|.||:||||:::||..:..|.|::.|.:|||||:.|.
Frog    69 GLSIKGGSEHNIPVVISKISKEQRAELSGLLFIGDAILQINGINVRKCKHEEVVQVLRNAGEEVT 133

  Fly   155 LTVKHYRAATPFLQKQLTKD---TPDSDNDVTCAELKADEGYKSSVN-SGTISRSCSR-PMSICS 214
            |||...:.:..||:..|.:|   .|...:..|.:.| .|.|...:.: :.|.|.|||. |.|...
Frog   134 LTVSFLKRSPAFLKLPLNEDCSCVPCDQSSGTSSPL-CDSGLHLNYHPNNTDSLSCSSWPTSPGL 197

  Fly   215 EPEKRWTDVVAVPLMMAYVTRYIYGTDKLRQNAFEVRGLNGISTGVIHCDELAILSQ----WLKL 275
            ..||||.|:..:||:.:.::::|.|||..|||||:|..::|:.:|:|.|    :|::    ||:.
Frog   198 RWEKRWCDLRLIPLLHSRLSQHITGTDLCRQNAFQVTAVDGVGSGIIQC----LLAEECIDWLQS 258

  Fly   276 ITDNVVGLTHLQMKLYNRNFAVGERIEYMGWVNEGVINNNISWQSYKPRFLLLKGTEVMLFETPP 340
            |:.|:..||...:|..||||.|.::|.::|||.|.. .:.:....|.|:||.|:|:.:..|.:||
Frog   259 ISANISNLTKHNIKKINRNFPVNQQIVFLGWVEERE-QDTLKDYVYSPKFLALRGSSLYKFNSPP 322

  Fly   341 LNVAGISKALVVYKVYQTMFRIVKESETVDSRQHCFLLQSSGHEPRYLSVETRQELLRIENSWNA 405
            :......:|...:.||:.|.:|.|:|:.:|.|:|||.:||...|..|.|||...:||:.|.::..
Frog   323 VTTWDWMRAEKKFTVYEIMCKIFKDSDLLDRRKHCFGVQSETGEDLYFSVELECDLLQWEKAFQT 387

  Fly   406 AIVTSVIKLGRKTFAVSHHGKSGGLTLDWQAGFSLTEGAESATVWQYKFSQLRGSSDDGKSKLKL 470
            |....|.::..||:|........|||:|:..||...:.|..|.:|:||||||:|||||||||:|.
Frog   388 ATFLEVERIQCKTYACVIESHLMGLTIDFGMGFICFDAATKAILWKYKFSQLKGSSDDGKSKIKF 452

  Fly   471 HFQDHDSRAIETKELECQVLQSLLFCMHAFLTAKVASVDPAFLSS 515
            .||:.|::.||.||||...|.::|.|:|:|..||||.:||.|:.|
Frog   453 LFQNQDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACLDPRFVDS 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Syn2	NP_788381.1	PDZ_signaling	76..158	CDD:238492	44/81 (54%)
Syn2	NP_788381.1	PH	301..407	CDD:214574	36/105 (34%)
sntg1	XP_004915254.1	PDZ_signaling	55..136	CDD:238492	43/80 (54%)
sntg1	XP_004915254.1	PH-like	288..381	CDD:388408	34/93 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	235	1.000	Domainoid score	I2312
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56834
Inparanoid	1	1.050	352	1.000	Inparanoid score	I2213
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1103724at2759
OrthoFinder	1	1.000	-	-		FOG0003391
OrthoInspector	1	1.000	-	-		otm47749
Panther	1	1.100	-	-	O	PTHR10554
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4001
SonicParanoid	1	1.000	-	-		X2288
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190