Protein Alignment loopin-1 and NPEPL1

DIOPT Version :10

• Sequence 1: NP_611134.1
• Gene: loopin-1 / 36847
• FlyBaseID: FBgn0259795
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_078939.3
• Gene: NPEPL1 / 79716
• HGNCID: 16244
• Length: 523
• Species: Homo sapiens
• Alignment Length: 391
• Identity: 100/391 - (25%)
• Similarity: 153/391 - (39%)
• Gaps: 60/391 - (15%)

  Fly   142 GMYEVHVDSMDYPEQAAEGAALA------VWRYNANKRKKNRIQTPKLDMYGKGDRDAWVRGL-- 198
            |.:...|...:.||..|...|||      ..|..|::|.:.:..|.:..:.|:.:....|..|
Human   106 GAHRCIVMVCEQPEVFASACALARAFPLFTHRSGASRRLEKKTVTVEFFLVGQDNGPVEVSTLQC 170

  Fly   199 --FKAESQNLARRLSDTPANMMTPSIFAQAAVDALCPCGVSVEVRSMDWIEDMNLNSFLMIAKGS 261
              ...:...||.|:.|||.|.|....|.:.........|:...:...:.::.........:.|.:
Human   171 LANATDGVRLAARIVDTPCNEMNTDTFLEEINKVGKELGIIPTIIRDEELKTRGFGGIYGVGKAA 235

  Fly   262 CEPPLLLECSYCGTTPE--DRPVLLLGQGLTFHSGGLCLKPKTGMDQYRGAMAGAAVCVGVLRAA 324
            ..||.|...|:   ||:  .:.:..:|:|:.:.:|||.:|.||.|...:....|||..:|..|||
Human   236 LHPPALAVLSH---TPDGATQTIAWVGKGIVYDTGGLSIKGKTTMPGMKRDCGGAAAVLGAFRAA 297

  Fly   325 AALSLPLNITAVMPLCEHMPSGMAVKCGDVVTLLNGTTMGIKNVDKAPVVQLADPLLYAQATYKP 389
            .......|:.||..|.|:.....|.:..|:..|.:|.|:.|.|.|....:.|||.:.||......
Human   298 IKQGFKDNLHAVFCLAENSVGPNATRPDDIHLLYSGKTVEINNTDAEGRLVLADGVSYACKDLGA 362

  Fly   390 KLVIDIGTVAMGVNYAVGGGASGLWT--------TSKSVWQ-NFRKSGGLTGDRVWRFPL----- 440
            .:::|:.|:.         ||.|:.|        |:.:.|: ...|:|...||.|  .||
Human   363 DIILDMATLT---------GAQGIATGKYHAAVLTNSAEWEAACVKAGRKCGDLV--HPLVYCPE 416

  Fly   441 --FKYYKQIV--NKNITYDLCNTGRGPASSCLAAAILHTL---VPCAEWAHLDI--------RGT 490
              |..:...|  .||...|..|:    .|||....|...:   .| ..|.||||        |.|
Human   417 LHFSEFTSAVADMKNSVADRDNS----PSSCAGLFIASHIGFDWP-GVWVHLDIAAPVHAGERAT 476

  Fly   491 G 491
            |
Human   477 G 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
loopin-1	NP_611134.1	Peptidase_M17_N	44..173	CDD:426984	10/36 (28%)
		Peptidase_M17	206..514	CDD:459978	85/317 (27%)
NPEPL1	NP_078939.3	Peptidase_M17	35..487	CDD:238247	100/391 (26%)