DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Sema2a and SEMA6D

DIOPT Version :9

Sequence 1:NP_477507.1 Gene:Sema2a / 36846 FlyBaseID:FBgn0011260 Length:724 Species:Drosophila melanogaster
Sequence 2:NP_001345281.1 Gene:SEMA6D / 80031 HGNCID:16770 Length:1086 Species:Homo sapiens


Alignment Length:773 Identity:238/773 - (30%)
Similarity:355/773 - (45%) Gaps:199/773 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 LLALLLLLCSSVSETAA-----DYE--NTWNFYYER--PCCTGNDQGNNNYGKHGADHVREFNCG 64
            |.|.:|||  .||:..|     |.|  ||.:::|.|  |...|...||.      :.|..:|.. 
Human     6 LCAYILLL--MVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNE------SQHRLDFQL- 61

  Fly    65 KLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVI-NLEPT----RDDVVSCVSKGKS 124
                    |.:.|||||:...|:|:.|||..:..:    :|| |.:.|    :.|..:|..|||.
Human    62 --------MLKIRDTLYIAGRDQVYTVNLNEMPKT----EVIPNKKLTWRSRQQDRENCAMKGKH 114

  Fly   125 QIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCPYDPLD 189
            : .:|.|.::|....:. :.::||||||.||  ...|..|:.|   ||......|:|:||:|...
Human   115 K-DECHNFIKVFVPRND-EMVFVCGTNAFNP--MCRYYRLSTL---EYDGEEISGLARCPFDARQ 172

  Fly   190 NSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPN 254
            .:.|::.:.       .|||.|.|:|..:|.||:|: :.:.||       .||:||||||:.:|:
Human   173 TNVALFADG-------KLYSATVADFLASDAVIYRS-MGDGSA-------LRTIKYDSKWIKEPH 222

  Fly   255 FVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGG-KNLLAHNWATYLKARLNCSIS 318
            |:.:.:.|.||||||||.|||:.|.|||||||:||:||.|:|| :.:|..:|.::||||||||:.
Human   223 FLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVP 287

  Fly   319 GEFPFYFNEIQSVYQ------LPSDKSRFFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQS 377
            |:..|||:.:||:..      :|:    ....|||..|.:.|||||:|.:::|:..|.|:||||.
Human   288 GDSFFYFDVLQSITDIIQINGIPT----VVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQK 348

  Fly   378 SSNSAWLPVLNSRVPEPRPGTCVN-------DTS-NLPDTVLNFIRSHPLMDKAVNHEHNNPVYY 434
            :.:|.|..|...:||:||||.|..       .|| :.||..|:||:||||||.||....:.|   
Human   349 TPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEP--- 410

  Fly   435 KRDLVFTKLVVDKIRIDILN--------QEYIVYYVGTNLGRIYKIV----QYYRNGESLSKLLD 487
                .|||..| :.|:..::        |.|.|.:||:..|.:.|::    .:..|...|.:.::
Human   411 ----WFTKTRV-RYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIE 470

  Fly   488 IFE----VAPNE---AIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFR-CV--RDPYCG 542
            .:.    .|.||   .:..:::.:...:||:.....|.:|.|:.| .||.:|.: |:  ||||||
Human   471 AYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRC-ERYGSCKKSCIASRDPYCG 534

  Fly   543 WDKEANTCRPYELDLLQDVANETSDICDSSVLKKKIVVTYGQSVHLGCFVKIPEVLKNEQVTWYH 607
            |..:.:..|                            ||.|.            :|..|....:|
Human   535 WLSQGSCGR----------------------------VTPGM------------LLLTEDFFAFH 559

  Fly   608 HSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRYDCHLGGSLLCSYNITVDAHRCTPPNKS 672
            :...:|          |.:.||.|      |.|       |||           |.|...|.:.:
Human   560 NHSAEG----------YEQDTEFG------NTA-------HLG-----------DCHEILPTSTT 590

  Fly   673 NDYQKIYSDWCHEFE---KYKTAMKS-----------WEKKQAQCSTRQNFSSNQHPN 716
            .|| ||:.....:.|   ...|.|.|           |..|   .::.:.|.....||
Human   591 PDY-KIFGGPTSDMEVSSSSVTTMASIPEITPKVIDTWRPK---LTSSRKFVVQDDPN 644

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Sema2aNP_477507.1 Sema_2A 66..523 CDD:200499 172/495 (35%)
Ig_Semaphorin_C 573..664 CDD:143180 17/90 (19%)
SEMA6DNP_001345281.1 Sema_6D 49..513 CDD:200530 176/516 (34%)
PSI 514..>543 CDD:307546 12/29 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 757..788
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..838
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 852..887
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 927..1018
Herpes_BLLF1 944..>1080 CDD:330317
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1034..1086
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3611
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11036
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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