DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and LOC798168

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	XP_009290884.1	Gene:	LOC798168 / 798168	-ID:	-	Length:	739	Species:	Danio rerio

Alignment Length:	693	Identity:	187/693 - (26%)
Similarity:	313/693 - (45%)	Gaps:	110/693 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 TFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFDCKNHVR 134
            |..::.|.|||:|||.|.:|.:::.. |.|...:|.:...|:.|...:|....|   .||.|.:.
Zfish    53 TLLLSTDEDTLFVGARDALFSLDVSQ-SDSITLKDELKWTPSSDQTKTCRVASK---LDCGNFIS 113

  Fly   135 VIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAK--CPYDPLDNSTAIYVE 197
            ::|..: ...||.|||||:.|:..:|       |.|.....:....||  ||:.....:|||.|:
Zfish   114 ILQFFN-STHLYACGTNAYKPQAIII-------PASSLNANIDKKDAKNCCPFSSTQRNTAIIVD 170

  Fly   198 NGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFDI- 261
            .       .||:.||..|.....||.|.....|. ..||      |:...|.|.:|.|:.|..:
Zfish   171 G-------ELYTATNVGFFGDKNVISRCHSRGTH-NNLE------LETVPKLLQEPVFISSTHVA 221

  Fly   262 --GEYVYFFFR--ETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISGEFP 322
              |:.:.||..  :.:.:|......| ||:|:||..|.||...|...|.::.||:|.|. .|| .
Zfish   222 SEGKILLFFTENGDLSGDYFGNSFTV-SRVAQVCTDDNGGTLTLQRRWTSFAKAQLVCQ-QGE-D 283

  Fly   323 FYFNEIQSVYQL-PS-----DKSRFFATFTTS---TNGLIGSAVCSFHINEIQAAFNGKFKEQSS 378
            ..||::|.:.:| ||     ||:.|:..||:.   ::||  ||||:|.:.:|:|||:|.:|....
Zfish   284 LQFNKLQDIVKLSPSDSDSPDKTLFYGVFTSQRSVSSGL--SAVCAFSLTDIKAAFSGNYKTFDL 346

  Fly   379 SNSAWLPVLNSRVPEPRPGTC--VNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFT 441
            ..:.|.|..|:   :.:.|.|  .|||    |:|||.::...|.:..|:......:....:..:|
Zfish   347 RGNHWSPQPNT---DGKLGKCGLFNDT----DSVLNRVKKSFLTENVVHPMDKTLLLSSAEEQYT 404

  Fly   442 KLVVDKIR-IDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAPNEAIQVMEISQT 505
            :|.|.:.: :|  .|.|.:.|:.|..|.::|:| ....|..:.:.:.||: .|..|..:: :|::
Zfish   405 RLAVHRAQAVD--GQTYTILYLLTESGFLHKVV-LLAEGPHIIEEIQIFK-QPQIAKNIL-LSKS 464

  Fly   506 RKSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDKEANTCRPY---ELDLLQDVANET 565
            :..|:||:...:.::.|:.|: .|.||..||  |||:|.||.|...|...   :..|.|||  |.
Zfish   465 KSVLFIGSSEGVFRVPLSNCS-AYPNCAECVLARDPFCAWDTETRACTAVSETKSTLRQDV--ER 526

  Fly   566 SDICDSSVLKKKIVVTYGQSVHLGCFVKIPEVLKNE--QVTWYHHSKDKGRYEIRYSPTK----- 623
            .::.:..:..:.......::.||...|.:|...|::  ::||            |:|...
Zfish   527 GNVTEQCIEFRNTAAVLFKTAHLNEIVVLPCQSKSKLAKMTW------------RFSNNSLVPQF 579

  Fly   624 -YIETTERGLVVVSVNEADGGRYDC---HLG-GSLLCSYNI---TVDAHRCTPPNKSN---DYQK 677
             |::.|: |.:|..|:......|.|   .|| ...:.::::   .|...|.:|.::..   |:..
Zfish   580 PYLQWTD-GSLVFPVSLETTNTYRCVSEELGFQQTIATFSVNLPVVPRSRMSPSHQQPEHIDFTT 643

  Fly   678 IYSDWCHEFEKYKTAMKSWEK---------KQAQCSTRQNFSS 711
            |..|......:.|...:|.||         |...|.:::::.|
Zfish   644 IELDESEPINEEKINDRSEEKQASTYHDAGKDTLCISQKSYYS 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	136/471 (29%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	19/105 (18%)
LOC798168	XP_009290884.1	Sema_4	43..482	CDD:200501	136/471 (29%)
		PSI	483..527	CDD:214655	19/46 (41%)
		Ig_Sema4B_like	540..624	CDD:143280	18/96 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010