DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2a and SEMA3B

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001276990.1	Gene:	SEMA3B / 7869	HGNCID:	10724	Length:	754	Species:	Homo sapiens

Alignment Length:	693	Identity:	200/693 - (28%)
Similarity:	299/693 - (43%)	Gaps:	160/693 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 WN----FYYERPCCTGNDQGNNNYGKHGADHVREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRV 91
            |:    |..||.||                           |:...::|:|..|:|||.:.|..:
Human    41 WHGLQTFSLERTCC---------------------------YQALLVDEERGRLFVGAENHVASL 78

  Fly    92 NLQNISS--------------SNCNRDVINLEPTRDDVVSCVSKGKSQIFDCKNHVRVIQSMDQG 142
            ||.|||.              ..||                 ..||....:|.|.|:::.:.::
Human    79 NLDNISKRAKKLAWPAPVEWREECN-----------------WAGKDIGTECMNFVKLLHAYNR- 125

  Fly   143 DRLYVCGTNAHNPKDYVIYANLTHLPRSEYVI------GVGLGIAKCPYDPLDNSTAIYVENGNP 201
            ..|..|||.|.:|.  ..:..:.|  |:|..:      .:..|..|.||||...:.::.|..
Human   126 THLLACGTGAFHPT--CAFVEVGH--RAEEPVLRLDPGRIEDGKGKSPYDPRHRAASVLVGE--- 183

  Fly   202 GGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFDIGE--- 263
                .||||..|:....|..|||:.....|.        ||..:||:||::|.||..|.|.|
Human   184 ----ELYSGVAADLMGRDFTIFRSLGQRPSL--------RTEPHDSRWLNEPKFVKVFWIPESEN 236

  Fly   264 ----YVYFFFRETAVEYINC-GKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISG-EFP 322
                .:||||||||||.... |:...||:.::|:.||||:..|.:.|.|:|||||.||:.| |..
Human   237 PDDDKIYFFFRETAVEAAPALGRLSVSRVGQICRNDVGGQRSLVNKWTTFLKARLVCSVPGVEGD 301

  Fly   323 FYFNEI-----QSVYQLPSDKSR---FFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSS 379
            .:|:::     :.|:.|.|...|   .:|.|:||::...|||||.:.:|:::.||.|.|..:...
Human   302 THFDQLRPFPAEDVFLLSSRDHRTPLLYAVFSTSSSIFQGSAVCVYSMNDVRRAFLGPFAHKEGP 366

  Fly   380 NSAWLPVLNSRVPEPRPGTC-------VNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYK-- 435
            ...|:. ...|||.||||.|       .:.|.:.||.|:.|.|:||||..:|......|::.:
Human   367 MHQWVS-YQGRVPYPRPGMCPSKTFGTFSSTKDFPDDVIQFARNHPLMYNSVLPTGGRPLFLQVG 430

  Fly   436 RDLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGES-----LSKLLDIFEVAPNE 495
            .:..||::..|  |:...:..|.|.::||::|.:.|::...:....     |.:.|.:||  .:.
Human   431 ANYTFTQIAAD--RVAAADGHYDVLFIGTDVGTVLKVISVPKGSRPSAEGLLLEELHVFE--DSA 491

  Fly   496 AIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKEANTCRPYELDL- 557
            |:..|:||..|..||:.:...:.||.|..|......|..|  .|||||.||..|  |..::...
Human   492 AVTSMQISSKRHQLYVASRSAVAQIALHRCAAHGRVCTECCLARDPYCAWDGVA--CTRFQPSAK 554

  Fly   558 ----LQDVAN-ETSDIC--DSS---VLKKKIVVTYGQSVHLGCFVKIPEVLKNEQVTWYHHSKDK 612
                .|||.| :.|.:|  |||   :|:.|:....|.|..|.|   .|..|: .:|.|...
Human   555 RRFRRQDVRNGDPSTLCSGDSSRPALLEHKVFGVEGSSAFLEC---EPRSLQ-ARVEWTFQ---- 611

  Fly   613 GRYEIRYSPTKY--------IETTERGLVVVSVNEADGGRYDC 647
                 |...|.:        .|.|.|||::..:...|.|.|.|
Human   612 -----RAGVTAHTQVLAEERTERTARGLLLRRLRRRDSGVYLC 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	151/507 (30%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	21/83 (25%)
SEMA3B	NP_001276990.1	Sema	46..521	CDD:301699	157/543 (29%)
		PSI	520..>556	CDD:214655	12/37 (32%)
		Ig_Semaphorin_classIII	580..670	CDD:143279	21/83 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	707..754
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920