DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2a and SEMA4A

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001180229.1	Gene:	SEMA4A / 64218	HGNCID:	10729	Length:	761	Species:	Homo sapiens

Alignment Length:	692	Identity:	196/692 - (28%)
Similarity:	313/692 - (45%)	Gaps:	131/692 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LQLSPLLALLLLLCSS----------VSETAADYENTWNFYYERPCCTGNDQGNNNYGKHGADHV 58
            |.|..||.|||...::          |...|.|.....:|::::
Human    16 LFLFQLLQLLLPTTTAGGGGQGPMPRVRYYAGDERRALSFFHQK--------------------- 59

  Fly    59 REFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLE-----PTRDDVVS- 117
                 |...:.|..::.|.:||||||.:.:..:::|       :..|..|:     |..|...|
Human    60 -----GLQDFDTLLLSGDGNTLYVGAREAILALDIQ-------DPGVPRLKNMIPWPASDRKKSE 112

  Fly   118 CVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPK-DYVIYANLTHLPRSEYVIGVGLGIA 181
            |..|.||....|.|.:||:.|.:. ..||.|||.|.:|. .::...:...||.||..:..|.|
Human   113 CAFKKKSNETQCFNFIRVLVSYNV-THLYTCGTFAFSPACTFIELQDSYLLPISEDKVMEGKG-- 174

  Fly   182 KCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYD 246
            :.|:||....||:.|:     |:  |||||...|..::.::.|| |.:....:.: .|.|.|.:|
Human   175 QSPFDPAHKHTAVLVD-----GM--LYSGTMNNFLGSEPILMRT-LGSQPVLKTD-NFLRWLHHD 230

  Fly   247 SKWLDKPNFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKA 311
            :      :||.:....:.|||||.|||.|:....:...||:|||||.||||:.||...|.|:|||
Human   231 A------SFVAAIPSTQVVYFFFEETASEFDFFERLHTSRVARVCKNDVGGEKLLQKKWTTFLKA 289

  Fly   312 RLNCSISGEFPFYFNEIQSVYQLPSDK---SRFFATFTT--STNGLIGSAVCSFHINEIQAAFNG 371
            :|.|:..|:.|  ||.|:....||:|.   ...:|.||:  ...|...||||:|.:.:|:..|.|
Human   290 QLLCTQPGQLP--FNVIRHAVLLPADSPTAPHIYAVFTSQWQVGGTRSSAVCAFSLLDIERVFKG 352

  Fly   372 KFKEQSSSNSAWLPVLNSRVPE--PRPGTCVNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYY 434
            |:||.:...|.|   ...|.||  ||||:|....|:  |..|.|::.|.|||:.|   ...|:..
Human   353 KYKELNKETSRW---TTYRGPETNPRPGSCSVGPSS--DKALTFMKDHFLMDEQV---VGTPLLV 409

  Fly   435 KRDLVFTKLVVDKIR-IDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAPN-EAI 497
            |..:.:|:|.|:..: :|  ...::|.|:||..|.::|.|.   :|:|.:.|::..::.|: |.:
Human   410 KSGVEYTRLAVETAQGLD--GHSHLVMYLGTTTGSLHKAVV---SGDSSAHLVEEIQLFPDPEPV 469

  Fly   498 QVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDKEANTC----RPYELD 556
            :.::::.|:.::::|....:.::..|.|: .|::|..||  |||:|.||.|:.||    .|....
Human   470 RNLQLAPTQGAVFVGFSGGVWRVPRANCS-VYESCVDCVLARDPHCAWDPESRTCCLLSAPNLNS 533

  Fly   557 LLQDVANETSD-ICDSSVLK------------KKIVVTYGQSVHLGCFVKIPEVLKNEQVTWYHH 608
            ..||:.....: .|.|..:.            |:::......:.|.|    |.:.......|.|
Human   534 WKQDMERGNPEWACASGPMSRSLRPQSRPQIIKEVLAVPNSILELPC----PHLSALASYYWSH- 593

  Fly   609 SKDKGRYEIRYSPTKYIE---TTERGLVVVSVNEADGGRYDC 647
                       .|....|   |...|.:::.|.:..||.|.|
Human   594 -----------GPAAVPEASSTVYNGSLLLIVQDGVGGLYQC 624

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	149/472 (32%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	15/90 (17%)
SEMA4A	NP_001180229.1	Sema_4A	55..495	CDD:200517	151/505 (30%)
		PSI	496..541	CDD:214655	17/45 (38%)
		Ig	566..638	CDD:353325	15/75 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	722..749
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870