DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and SEMA3F

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_004177.3	Gene:	SEMA3F / 6405	HGNCID:	10728	Length:	785	Species:	Homo sapiens

Alignment Length:	681	Identity:	208/681 - (30%)
Similarity:	316/681 - (46%)	Gaps:	132/681 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GADHVREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRD--VINLEPTRDDVV 116
            |..|...|......||....:||.|.:|||:.|.|..::|.:|     ||:  :|:...:...:.
Human    43 GTAHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDI-----NREPLIIHWAASPQRIE 102

  Fly   117 SCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYAN------------------ 163
            .||..||....:|.|.||:||..:: ..||||||.|:||  ...|.|
Human   103 ECVLSGKDVNGECGNFVRLIQPWNR-THLYVCGTGAYNP--MCTYVNRGRRAQATPWTQTQAVRG 164

  Fly   164 ------------LTHLPRSEYVI-----GVGLGIAKCPYDP-LDNSTAIYVENGNPGGLPGLYSG 210
                        :...||.:|:.     .:..|..|||||| ||.::|:..|.        ||:|
Human   165 RGSRATDGALRPMPTAPRQDYIFYLEPERLESGKGKCPYDPKLDTASALINEE--------LYAG 221

  Fly   211 TNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFDI-------GEYVYFF 268
            ...:|...|..||||....|:        .||.:|:|:||:.|:|:.:..|       .:.:|||
Human   222 VYIDFMGTDAAIFRTLGKQTA--------MRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLYFF 278

  Fly   269 FRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISGE--FPFYFNEIQSV 331
            |||.:.|... ..|||:||.|:|..|.||...|.:.|:|:|||||.||:.||  ...:|:|:|.|
Human   279 FRERSAEAPQ-SPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIETHFDELQDV 342

  Fly   332 YQLPSDKSR---FFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPE 393
            :...:...|   .:|.||:|.:...|||||.:.:.:|:..|||.|..:...|..|:| .:.::|.
Human   343 FVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEGPNYQWMP-FSGKMPY 406

  Fly   394 PRPGTC--------VNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVF--TKLVVDKI 448
            ||||||        :..|.:.||.|:||:||||||.:||......|:..:....:  |.:.||
Human   407 PRPGTCPGGTFTPSMKSTKDYPDEVINFMRSHPLMYQAVYPLQRRPLVVRTGAPYRLTTIAVD-- 469

  Fly   449 RIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKL-LDIFEVAPNEA-IQVMEISQTRKSLYI 511
            ::|..:..|.|.::||:.|.:.|::...::.:.|.:| |:..||..:.| ::.|.||..|:.||:
Human   470 QVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQELEELMLEEVEVFKDPAPVKTMTISSKRQQLYV 534

  Fly   512 GTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKEANTCRPY-----ELDLLQDV-------- 561
            .:...:..:.|..|......|..|  .|||||.||.:|  |..|     .....|||
Human   535 ASAVGVTHLSLHRCQAYGAACADCCLARDPYCAWDGQA--CSRYTASSKRRSRRQDVRHGNPIRQ 597

  Fly   562 -----ANETSDICDSSVLKKKIVVTY---GQSVHLGCFVKIPEVLKNEQVTWYHHSKDKG--RYE 616
                 :|...:..:|        |.|   |.:..|.|..:.|:.    .|.|. ..:|.|  |.|
Human   598 CRGFNSNANKNAVES--------VQYGVAGSAAFLECQPRSPQA----TVKWL-FQRDPGDRRRE 649

  Fly   617 IRYSPTKYIETTERGLVVVSVNEADGGRYDC 647
            || :..:::. ||:||::.::..:|.|.|.|
Human   650 IR-AEDRFLR-TEQGLLLRALQLSDRGLYSC 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	164/518 (32%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	22/80 (28%)
SEMA3F	NP_004177.3	Sema_3F	48..548	CDD:200515	166/527 (31%)
		PSI	547..584	CDD:214655	13/38 (34%)
		Ig_Semaphorin_classIII	609..697	CDD:143279	23/85 (27%)
		IG_like	612..696	CDD:214653	23/82 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	752..785
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11345
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.910