Protein Alignment Sema2a and SEMA4G

DIOPT Version :10

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: NP_060363.2
• Gene: SEMA4G / 57715
• HGNCID: 10735
• Length: 843
• Species: Homo sapiens
• Alignment Length: 688
• Identity: 199/688 - (28%)
• Similarity: 291/688 - (42%)
• Gaps: 142/688 - (20%)

  Fly    59 REFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGK 123
            |.|......|.|..:.|....|.|||...:|.::..:| ....::: |:.|.:.:....|..|||
Human    47 RHFKGQAQNYSTLLLEEASARLLVGARGALFSLSANDI-GDGAHKE-IHWEASPEMQSKCHQKGK 109

  Fly   124 SQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCPYDPL 188
            :...:|.||||.:|.:: ...||.|||:|..|....|.|....||.|     ...|..||||||.
Human   110 NNQTECFNHVRFLQRLN-STHLYACGTHAFQPLCAAIDAEAFTLPTS-----FEEGKEKCPYDPA 168

  Fly   189 DNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFK-RTLKYDSKWLDK 252
            ...|.:.::.       |||:.|..||.....:           :|..:... ||.:....||:.
Human   169 RGFTGLIIDG-------GLYTATRYEFRSIPDI-----------RRSRHPHSLRTEETPMHWLND 215

  Fly   253 PNFVGSFDIGE----------YVYFFFRETAVEYINCGKAVY---------SRIARVCKKDVGGK 298
            ..||.|..:.|          .||:||.|.|.|.   |...:         :|:|||||.|:|||
Human   216 AEFVFSVLVRESKASAVGDDDKVYYFFTERATEE---GSGSFTQSRSSHRVARVARVCKGDLGGK 277

  Fly   299 NLLAHNWATYLKARLNCSISGEFPFYFNEIQSVYQL---PSDKSRFFATFTTST--NGLIGSAVC 358
            .:|...|.::|||||.|.|    |.| ..::.|..|   .|.::.|:|.||.||  ..|..||:|
Human   278 KILQKKWTSFLKARLICHI----PLY-ETLRGVCSLDAETSSRTHFYAAFTLSTQWKTLEASAIC 337

  Fly   359 SFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCV---------NDTSNLPDTVLNFI 414
            .:.:.||||.|.|.:.|....:..| ......|||||||:|:         |.:.:||..||:|:
Human   338 RYDLAEIQAVFAGPYMEYQDGSRRW-GRYEGGVPEPRPGSCITDSLRSQGYNSSQDLPSLVLDFV 401

  Fly   415 RSHPLMDKAVNHEHNNPVYYKRDLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIV------ 473
            :.||||.:.|......|:..||::.:|.|....:... ....|.:.::||..|.|:|.|
Human   402 KLHPLMARPVVPTRGRPLLLKRNIRYTHLTGTPVTTP-AGPTYDLLFLGTADGWIHKAVVLGSGM 465

  Fly   474 ------QYYRNGESLSKLLDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNC 532
                  |.:|..:|:..|:               ||..:.|||:|....:.|:.|:.|: ||.:|
Human   466 HIIEETQVFRESQSVENLV---------------ISLLQHSLYVGAPSGVIQLPLSSCS-RYRSC 514

  Fly   533 FRCV--RDPYCGWDKEANTC----------RPYELDLLQDVANETSDICDSS-------VLKKKI 578
            :.|:  ||||||||...:.|          :.....|:||:...... |:||       .||.:.
Human   515 YDCILARDPYCGWDPGTHACAAATTIANRSQGSRTALIQDIERGNRG-CESSRDTGPPPPLKTRS 578

  Fly   579 VVTYGQSVHLGCFVKIPEVLKNEQVTWYHH-----SKDKGRYEIRYSPTKYIETTERGLVVVSVN 638
            |:. |..|.|.|  ..|..|  .:..|..:     |..:|.|.:...          ||:|....
Human   579 VLR-GDDVLLPC--DQPSNL--ARALWLLNGSMGLSDGQGGYRVGVD----------GLLVTDAQ 628

  Fly   639 EADGGRYDCHL--GG--SLLCSYNITVDAHRCTPPNKS 672
            ....|.|.|:.  .|  :||.||::||......|..|:
Human   629 PEHSGNYGCYAEENGLRTLLASYSLTVRPATPAPAPKA 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	148/502 (29%)
		PSI	527..>550	CDD:396154	12/24 (50%)
		Ig_Semaphorin_C	573..668	CDD:409368	26/103 (25%)
		Ig strand A	573..579	CDD:409368	2/5 (40%)
		Ig strand B	583..591	CDD:409368	3/7 (43%)
		Ig strand C	601..607	CDD:409368	1/5 (20%)
		Ig strand C'	609..612	CDD:409368	1/2 (50%)
		Ig strand D	622..626	CDD:409368	0/3 (0%)
		Ig strand E	630..637	CDD:409368	3/6 (50%)
		Ig strand F	643..652	CDD:409368	4/12 (33%)
		Ig strand G	655..668	CDD:409368	4/12 (33%)
SEMA4G	NP_060363.2	Sema_4G	47..506	CDD:200523	150/509 (29%)
		PSI	507..>534	CDD:396154	13/27 (48%)
		Ig_Sema4B_like	572..655	CDD:409456	24/97 (25%)
		Ig strand A	572..578	CDD:409456	2/5 (40%)
		Ig strand B	582..590	CDD:409456	4/9 (44%)
		Ig strand C	596..602	CDD:409456	1/5 (20%)
		Ig strand C'	604..607	CDD:409456	0/2 (0%)
		Ig strand D	614..618	CDD:409456	1/3 (33%)
		Ig strand E	620..627	CDD:409456	3/16 (19%)
		Ig strand F	633..642	CDD:409456	3/8 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	728..782