DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Sema2a and SEMA4G

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_060363.2	Gene:	SEMA4G / 57715	HGNCID:	10735	Length:	843	Species:	Homo sapiens

Alignment Length:	688	Identity:	199/688 - (28%)
Similarity:	291/688 - (42%)	Gaps:	142/688 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 REFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGK 123
            |.|......|.|..:.|....|.|||...:|.::..:| ....::: |:.|.:.:....|..|||
Human    47 RHFKGQAQNYSTLLLEEASARLLVGARGALFSLSANDI-GDGAHKE-IHWEASPEMQSKCHQKGK 109

  Fly   124 SQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVGLGIAKCPYDPL 188
            :...:|.||||.:|.:: ...||.|||:|..|....|.|....||.|     ...|..||||||.
Human   110 NNQTECFNHVRFLQRLN-STHLYACGTHAFQPLCAAIDAEAFTLPTS-----FEEGKEKCPYDPA 168

  Fly   189 DNSTAIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFK-RTLKYDSKWLDK 252
            ...|.:.::.       |||:.|..||.....:           :|..:... ||.:....||:.
Human   169 RGFTGLIIDG-------GLYTATRYEFRSIPDI-----------RRSRHPHSLRTEETPMHWLND 215

  Fly   253 PNFVGSFDIGE----------YVYFFFRETAVEYINCGKAVY---------SRIARVCKKDVGGK 298
            ..||.|..:.|          .||:||.|.|.|.   |...:         :|:|||||.|:|||
Human   216 AEFVFSVLVRESKASAVGDDDKVYYFFTERATEE---GSGSFTQSRSSHRVARVARVCKGDLGGK 277

  Fly   299 NLLAHNWATYLKARLNCSISGEFPFYFNEIQSVYQL---PSDKSRFFATFTTST--NGLIGSAVC 358
            .:|...|.::|||||.|.|    |.| ..::.|..|   .|.::.|:|.||.||  ..|..||:|
Human   278 KILQKKWTSFLKARLICHI----PLY-ETLRGVCSLDAETSSRTHFYAAFTLSTQWKTLEASAIC 337

  Fly   359 SFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCV---------NDTSNLPDTVLNFI 414
            .:.:.||||.|.|.:.|....:..| ......|||||||:|:         |.:.:||..||:|:
Human   338 RYDLAEIQAVFAGPYMEYQDGSRRW-GRYEGGVPEPRPGSCITDSLRSQGYNSSQDLPSLVLDFV 401

  Fly   415 RSHPLMDKAVNHEHNNPVYYKRDLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIV------ 473
            :.||||.:.|......|:..||::.:|.|....:... ....|.:.::||..|.|:|.|
Human   402 KLHPLMARPVVPTRGRPLLLKRNIRYTHLTGTPVTTP-AGPTYDLLFLGTADGWIHKAVVLGSGM 465

  Fly   474 ------QYYRNGESLSKLLDIFEVAPNEAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNC 532
                  |.:|..:|:..|:               ||..:.|||:|....:.|:.|:.|: ||.:|
Human   466 HIIEETQVFRESQSVENLV---------------ISLLQHSLYVGAPSGVIQLPLSSCS-RYRSC 514

  Fly   533 FRCV--RDPYCGWDKEANTC----------RPYELDLLQDVANETSDICDSS-------VLKKKI 578
            :.|:  ||||||||...:.|          :.....|:||:...... |:||       .||.:.
Human   515 YDCILARDPYCGWDPGTHACAAATTIANRSQGSRTALIQDIERGNRG-CESSRDTGPPPPLKTRS 578

  Fly   579 VVTYGQSVHLGCFVKIPEVLKNEQVTWYHH-----SKDKGRYEIRYSPTKYIETTERGLVVVSVN 638
            |:. |..|.|.|  ..|..|  .:..|..:     |..:|.|.:...          ||:|....
Human   579 VLR-GDDVLLPC--DQPSNL--ARALWLLNGSMGLSDGQGGYRVGVD----------GLLVTDAQ 628

  Fly   639 EADGGRYDCHL--GG--SLLCSYNITVDAHRCTPPNKS 672
            ....|.|.|:.  .|  :||.||::||......|..|:
Human   629 PEHSGNYGCYAEENGLRTLLASYSLTVRPATPAPAPKA 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	148/502 (29%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	26/99 (26%)
SEMA4G	NP_060363.2	Sema_4G	47..506	CDD:200523	150/509 (29%)
		PSI	507..557	CDD:307546	17/50 (34%)
		Ig_Sema4B_like	572..655	CDD:143280	24/97 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	728..782
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870