Protein Alignment Sema2a and SEMA6A

DIOPT Version :9

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: XP_006714726.1
• Gene: SEMA6A / 57556
• HGNCID: 10738
• Length: 1052
• Species: Homo sapiens
• Alignment Length: 660
• Identity: 210/660 - (31%)
• Similarity: 319/660 - (48%)
• Gaps: 110/660 - (16%)

  Fly    32 NFYYERPCCTGNDQGNNNYGKHGADHVREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQNI 96
            |:..:.|...|:..|.|...:|..|          ......||   .|||:.|.|.::.|::...
Human    33 NYTKQYPVFVGHKPGRNTTQRHRLD----------IQMIMIMN---GTLYIAARDHIYTVDIDTS 84

  Fly    97 SSSN--CNRDVINLEPTRDDVVSCVSKGKSQIFDCKNHVRVIQSMDQGDRLYVCGTNAHNP--KD 157
            .:..  |::. :..:..:.||.:|..|||.: .:|.|.::|:...:. |.|:||||||.||  ::
Human    85 HTEEIYCSKK-LTWKSRQADVDTCRMKGKHK-DECHNFIKVLLKKND-DALFVCGTNAFNPSCRN 146

  Fly   158 YVIYANLTHLPRSEYVIGVG---LGIAKCPYDPLDNSTAIYVENGNPGGLPGLYSGTNAEFTKAD 219
            |          :.:.:...|   .|:|:||||....:.|::.:.       .|||.|..:|...|
Human   147 Y----------KMDTLEPFGDEFSGMARCPYDAKHANVALFADG-------KLYSATVTDFLAID 194

  Fly   220 TVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFDIGEYVYFFFRETAVEYINCGKAVY 284
            .||:|:        ..|....||:|:|||||.:|.||.:.|.|:|:||||||.||||...||.|:
Human   195 AVIYRS--------LGESPTLRTVKHDSKWLKEPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVF 251

  Fly   285 SRIARVCKKDVGG-KNLLAHNWATYLKARLNCSISGEFPFYFNEIQSVYQLPSDKSR--FFATFT 346
            .|:|:|||.|:|| :.:|...|.::||||||||:.|:..||||.:|:|..:.....|  ..|||:
Human   252 PRVAQVCKNDMGGSQRVLEKQWTSFLKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFS 316

  Fly   347 TSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPRPGTCVND-------TS 404
            |..|.:.|||||::.:.:|.:.|.|:||||.|.:|.|.||.:.|||:||||.|...       ||
Human   317 TPYNSIPGSAVCAYDMLDIASVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLERYATS 381

  Fly   405 N-LPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFTKLVVDKIRIDIL---NQEYIVYYVGTN 465
            | .||..||||::|||||:||....|.| ::.|.:|..:|.  ||.:|..   .|.:.|.::|:.
Human   382 NEFPDDTLNFIKTHPLMDEAVPSIFNRP-WFLRTMVRYRLT--KIAVDTAAGPYQNHTVVFLGSE 443

  Fly   466 LGRIYKIVQYYRNGESLSKLLDIFEVA------------PNEAIQVMEISQTRKSLYIGTDHRIK 518
            .|.|.|.:....|...|:..|.:.|::            .::.|..|::.:...|||:.....:.
Human   444 KGIILKFLARIGNSGFLNDSLFLEEMSVYNSEKCSYDGVEDKRIMGMQLDRASSSLYVAFSTCVI 508

  Fly   519 QIDLAMCNRRYDNCFR-CV--RDPYCGWDKEANTCRPY----ELDLLQDVANETSD---ICDSSV 573
            ::.|..| .|:..|.: |:  |||||||.||...|...    .|...||:....:|   .|.:|.
Human   509 KVPLGRC-ERHGKCKKTCIASRDPYCGWIKEGGACSHLSPNSRLTFEQDIERGNTDGLGDCHNSF 572

  Fly   574 LKKKIVVTYGQSVHLGCFVKIPEVLKNEQVTW--YHHSKDKGRYEIRYSPTKYIETTERGLVVVS 636
                :.:.....:.:.|.|    ::......|  :|.|      .:..|.|....|.:.|.
Human   573 ----VALNEANILFIMCMV----IILQGWSFWSCWHSS------SLLPSTTTSDSTAQEGY---- 619

  Fly   637 VNEADGGRYD 646
              |:.||..|
Human   620 --ESRGGMLD 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	169/489 (35%)
		Ig_Semaphorin_C	573..664	CDD:143180	13/76 (17%)
SEMA6A	XP_006714726.1	Sema_6A	48..513	CDD:200527	172/508 (34%)
		PSI	514..>544	CDD:307546	14/30 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.910