DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and sema4ba

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001121824.1	Gene:	sema4ba / 572261	ZFINID:	ZDB-GENE-070705-31	Length:	830	Species:	Danio rerio

Alignment Length:	811	Identity:	222/811 - (27%)
Similarity:	365/811 - (45%)	Gaps:	179/811 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLALLLLLCSSVSETAADYENTWNFYYERPCCTGNDQGNNNYGKHGADHVREFNCGKLYYRTFHM 73
            |..||:..|.|..:   |.....:|.|     ..|::....:...|.     ||     |.:..:
Zfish    15 LNVLLVGRCQSAED---DVTPRLSFSY-----NANERSAKRFSPSGV-----FN-----YTSLLL 61

  Fly    74 NEDRDTLYVGAMDRVFRVNLQNISSSNCNRDVINLEP--TRDDVVSCVSKGKSQIFDCKNHVRVI 136
            :::.:.|||||.:.:|.:|:.:||.:...|::....|  .||:   |..|||....||.|:::::
Zfish    62 SKEDNMLYVGARETLFALNISDISRTQMQRNLTWSTPQRKRDE---CSFKGKDLKTDCFNYIKIL 123

  Fly   137 QSMDQGDRLYVCGTNAHNP-KDYVIYANLTH--LPRSEYVIGVGL---GIAKCPYDPLDNSTAIY 195
            ..:: ...||||||.|.:| ..|::..|.::  |.|:|  :|..:   |.::|||:|...||||.
Zfish   124 LRVN-STHLYVCGTYAFSPICTYIVSTNTSNFSLVRNE--VGEIMTEDGRSRCPYNPEYKSTAIM 185

  Fly   196 VENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFD 260
            .:.       .||:||.:.|...|.:|:::....|:.|         .:....||..|.||||..
Zfish   186 ADG-------ELYAGTVSNFQGNDPIIYKSLGQGTALK---------TENSLNWLQDPAFVGSAY 234

  Fly   261 IGE------------YVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARL 313
            |.|            .:||||.|...|:......:.||||||||.|.||:.:|...|.|:|||:|
Zfish   235 IQESLPKGNAVGDDDKIYFFFSEAGKEFDFFDNTIVSRIARVCKGDKGGERVLQKKWTTFLKAQL 299

  Fly   314 NCSISGE-FPFYFNEIQSVYQL-PS----DKSRFFATFTTS-TNGLIG-SAVCSFHINEIQAAFN 370
            .||:..: ||  ||.||.::.| ||    .|:.|:..||:. ..|..| ||||:|.:::::.|||
Zfish   300 LCSLPDDGFP--FNIIQDMFVLTPSKEDWKKTMFYGVFTSQWYKGASGSSAVCAFTMDQVEEAFN 362

  Fly   371 GKFKEQSSSNSAWLPVLNSRVPEPRPGTCVNDTS---------NLPDTVLNFIRSHPLMDKAVNH 426
            |:::|.:.....|. ..|..|||||||.|:.:|:         ::||.||||::.|.|||..:
Zfish   363 GRYREVNRETQQWY-TYNHPVPEPRPGACITNTARAQGISSSLHMPDRVLNFVKDHFLMDNVI-- 424

  Fly   427 EHNNPVYYKRDLVFTKLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEV 491
             .:.|:..||::.:|:|.|.  |:..|::.|.|.::||:.|||:|.:    |.::...:::...:
Zfish   425 -RSQPLLLKRNVRYTQLAVH--RVQALHKTYDVLFIGTDDGRIHKAI----NVKNKMYIIEELVI 482

  Fly   492 APN-EAIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWD-------KE 546
            .|. :::|.:|:...:..|::.:...:.:|.||.|: .|.:|..||  |||||.|.       |.
Zfish   483 FPEPQSVQHIELDDEKGLLFVSSYSGLVEIPLANCS-NYQSCGECVLSRDPYCAWTGKQCSNVKH 546

  Fly   547 ANTCRPYELDLLQDVANETSDICDSSVLKK---KIVVTYGQSVHLGCFVKIPEVLKNEQVT--WY 606
            |::...::    |||.:..:.||.....:.   ::...:...:....|..:|..|::....  |
Zfish   547 ASSKSQWQ----QDVEDANTAICKMPSPRSGRPRVPACHVVEIPANTFTVLPCKLRSNLAARRW- 606

  Fly   607 HHSKDKGRYEIRYSPTKYIETTER--------GLVVVSVNE--------ADGGRYDCHLGGSLLC 655
                            :|.:|.||        |||||:..:        ::.|.|     ..||.
Zfish   607 ----------------EYSDTAERFVYPSPDGGLVVVAQVDRQENYACWSEEGNY-----RQLLA 650

  Fly   656 SYNITVDAHRCTPPNKSNDYQKIYSD-------WCHEFEKYKTAMKSWEKKQAQCS--------- 704
            ||.:..:....|...:|...|....:       |..  :|.||   .|.:....|:
Zfish   651 SYCVKAEHESTTLTGRSRTQQVTQGETILPGETWSP--QKTKT---YWNELIVVCALLVFSLVVL 710

  Fly   705 -------TRQNFSS----NQHPNEIFRKPNV 724
                   .|....|    .:.||...:||.:
Zfish   711 SLFVAYRNRDRMKSMLKEGECPNMQQKKPRI 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	156/494 (32%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	19/111 (17%)
sema4ba	NP_001121824.1	Sema_4B	47..515	CDD:200518	159/511 (31%)
		PSI	516..565	CDD:214655	16/53 (30%)
		Ig	578..654	CDD:299845	19/97 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010