Protein Alignment Sema2a and sema4ab

DIOPT Version :9

• Sequence 1: NP_477507.1
• Gene: Sema2a / 36846
• FlyBaseID: FBgn0011260
• Length: 724
• Species: Drosophila melanogaster
• Sequence 2: XP_005170153.1
• Gene: sema4ab / 571290
• ZFINID: ZDB-GENE-060503-363
• Length: 836
• Species: Danio rerio
• Alignment Length: 618
• Identity: 170/618 - (27%)
• Similarity: 281/618 - (45%)
• Gaps: 91/618 - (14%)

  Fly    70 TFHMNEDRDTLYVGAMDRVFRVNLQNISSSNCN-RDVINLEPTRDDVVSCVSKGKSQIFDCKNHV 133
            |..::.|..||:|||.|.:..:   |||.::.. ::.::..|:..|...|..|||.:: ||.|.|
Zfish    51 TLLLSNDEGTLFVGARDTILSI---NISQTDMTLKEKLDWSPSEKDFNDCSMKGKLKM-DCHNFV 111

  Fly   134 RVIQSMDQGDRLYVCGTNAHNPKDYVIYANLTHLPRSEYVIGVG------LGIAKCPYDPLDNST 192
            ||:|.:: ...:|.|||.|.:|:  .||.|     ...:.:..|      .|..:|||||...::
Zfish   112 RVLQVLN-STHMYACGTFAFSPR--CIYIN-----SQTFTMVTGPSGKPEEGRGRCPYDPYQKNS 168

  Fly   193 AIYVENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVG 257
            ||.|:.       .||:||.::|.....||.|   :.:....::.|...||    .||:.|.|:.
Zfish   169 AITVDG-------ELYTGTVSDFRGTRPVISR---HLSEGSHVDLKLDDTL----GWLEDPTFIS 219

  Fly   258 SFDI--GEYVYFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISGE 320
            |..|  .|.|||||.|...||....|...||:|:||..||||:..|...|.|:.||:|.|....|
Zfish   220 STYIHSEEKVYFFFSEIGKEYDFIDKFTVSRVAQVCTSDVGGQRTLQKRWTTFAKAQLLCQADQE 284

  Fly   321 FPFYFNEIQSVYQL------PSDKSRFFATFTTSTNGLIG-SAVCSFHINEIQAAFNGKFKEQSS 378
            .|  :|.:|.|..|      ..|::.|:..||:.....:| ||||:|.:.:|:..|.|::|..:.
Zfish   285 LP--YNVLQDVISLSPPEGASEDETLFYGIFTSQWRVNLGRSAVCAFSLKDIKKVFTGRYKVLNR 347

  Fly   379 SNSAWLPVLNSRVPE--PRPGTCVNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFT 441
            ....|    ::||.|  ..||.|  ...|..|..|.|::.:.|.||:|...:........|..::
Zfish   348 DTLKW----STRVQEQMANPGEC--GLHNASDNTLRFVKDNFLADKSVLPVNQGLTVVSPDKSYS 406

  Fly   442 KLVVDKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAPNEAIQVMEISQTR 506
            .:...::: ....:.|.|.|:.|..|.::|.| ..:.|..:.:.:.:|.  ..:.::.:.:|.::
Zfish   407 NIAAQRVQ-GARGKYYTVLYLLTESGFLHKTV-LLKKGAHIIEEIQVFH--QPQMVKSLLLSVSK 467

  Fly   507 KSLYIGTDHRIKQIDLAMCNRRYDNCFRCV--RDPYCGWDKEANTCR---PYELDLLQDV-ANET 565
            .::.||:...:..:.::.|: .|.:|..||  |||:||||.....|:   ..:..|.||| ..:.
Zfish   468 GAVLIGSSEGLLSVPVSNCS-HYRSCAECVLARDPFCGWDLSQRVCKLITTSQNQLAQDVDEGKV 531

  Fly   566 SDICDSSVLKKK----------------IVVTYGQSVHLGCFVKIPEVLKNEQVTWYHHSKDKGR 614
            |:.|.|..|:.:                :.|:..:.::|.|    ||.....:..|       .|
Zfish   532 SEQCSSVNLRSRSGQPQNTQTLCPPGEVLSVSLNEVINLQC----PEASNLAKCHW-------ER 585

  Fly   615 YEIRYSPTKYIETTERGLVVVSVNEADGGRYDC 647
            ...:.||..:|::....|..|: ..:..|.|.|
Zfish   586 LNSQLSPKIFIQSVNGSLSFVA-TPSTLGHYLC 617

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	134/470 (29%)
		Ig_Semaphorin_C	573..664	CDD:143180	16/91 (18%)
sema4ab	XP_005170153.1	Sema_4	41..484	CDD:200501	134/470 (29%)
		PSI	485..>512	CDD:214655	12/27 (44%)
		Ig	555..631	CDD:299845	15/75 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910