DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Sema2a and sema3b

DIOPT Version :9

Sequence 1:	NP_477507.1	Gene:	Sema2a / 36846	FlyBaseID:	FBgn0011260	Length:	724	Species:	Drosophila melanogaster
Sequence 2:	NP_001121818.1	Gene:	sema3b / 567064	ZFINID:	ZDB-GENE-081105-78	Length:	775	Species:	Danio rerio

Alignment Length:	750	Identity:	224/750 - (29%)
Similarity:	344/750 - (45%)	Gaps:	122/750 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 CCT--------------GNDQGNNNYGKHGADHVREFNCGKLY-------YRTFHMNEDRDTLYV 82
            |||              |:.|.:... |.....:::||..|.:       :....::|:|..|:|
Zfish     6 CCTLVLFGLIGISASLSGSSQSSPRM-KLSYKDLQQFNGIKRFDLERSCSFGALLLDEERGRLFV 69

  Fly    83 GAMDRVFRVNLQNISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFDCKNHVRVIQSMDQGDRLYV 147
            ||.:.:..::|.|||.   ....|......|....|...||....||.|:|:|:...:: ..||.
Zfish    70 GARNFLLSLSLDNISK---QEQKIYWPAPVDWREECNWAGKDINTDCVNYVKVLHHYNR-THLYA 130

  Fly   148 CGTNAHNPKDYVIYANL-----THLPRSEYVIGVGLGIAKCPYDPLDNSTAIYVENGNPGGLPGL 207
            |||.|.:|.  ..|..:     .|:.|.:..: |..|..|.||||...|.::.:.:       .|
Zfish   131 CGTGAFHPT--CAYVEVGQKMEDHVFRIDPSL-VEDGKGKSPYDPRHTSASVLIGD-------EL 185

  Fly   208 YSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKYDSKWLDKPNFVGSFDIGE-------YV 265
            |:|...:....|..|||:.....|.        ||.::||:||::|.|:.:|.:.|       .|
Zfish   186 YAGVATDLMGRDFTIFRSMGQKPSI--------RTEQHDSRWLNEPKFIAAFGVPESDNPDDDKV 242

  Fly   266 YFFFRETAVEYINCGKAVYSRIARVCKKDVGGKNLLAHNWATYLKARLNCSISGE--FPFYFNEI 328
            :|||||||||....||..||||.::|:.|:||:..|.:.|.|:|||||.||:.|.  ...:|:|:
Zfish   243 FFFFRETAVEAQGFGKVTYSRIGQLCRNDMGGQRSLVNKWTTFLKARLVCSVPGNDGTETHFDEL 307

  Fly   329 QSVYQLPS-DKSR--FFATFTTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSR 390
            :.|:.|.: ||..  .:..||||::...|||||.:.:|:|:.||.|.|..:...|..|:| ...:
Zfish   308 RDVFLLQTRDKKNPLIYTVFTTSSSVFQGSAVCLYTMNDIRRAFLGPFAHKEGPNYQWIP-FQGK 371

  Fly   391 VPEPRPGTC-------VNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDL--VFTKLVVD 446
            ||.||||.|       ...|...||.|:.|.|.||||...|......|::.:..:  .||::.||
Zfish   372 VPYPRPGMCPSKTFGSFESTKGFPDNVIQFARHHPLMFNPVTPLGGRPLFLRTGIPYTFTQITVD 436

  Fly   447 KIRIDILNQEYIVYYVGTNLGRIYKIVQY----YRNGESLSKLLDIFEVAPNEAIQVMEISQTRK 507
              |::..:..|.|.::||::|.:.|::..    :.|.|.|.:.|.:|:  .:.:|..|:||..|:
Zfish   437 --RVNAADGHYDVMFIGTDVGSVLKVISVPKGSWSNTELLLEELHVFK--DSSSIISMQISSKRQ 497

  Fly   508 SLYIGTDHRIKQIDLAMCNRRYDNCFRC--VRDPYCGWDKEANTCRPYELDL-----LQDVAN-E 564
            .||:|:|..:.|:.|..|:.....|..|  .|||||.||  .:||..|..:.     .|||.| :
Zfish   498 QLYVGSDTGVVQVPLHRCSMYGKACAECCLARDPYCAWD--GHTCTRYLPNTKRRFRRQDVRNGD 560

  Fly   565 TSDICDSS-----VLKKKIVVTYGQSVHLGCFVKIPEVLKNEQVTW-YHHSKDKGRYEIRYSPTK 623
            .:.:|...     ||:|::....|.|..|.|   :|:.|: .|:|| |....:..|.|:|..  :
Zfish   561 PNALCSGDHQKQRVLEKRLYAVDGSSSFLEC---VPKSLQ-AQITWTYQKLPENPREEVRLD--E 619

  Fly   624 YIETTERGLVVVSVNEADGGRYDCHLGGSLLCSYNITVDA-------HRCTPPNKSNDYQKIYSD 681
            .:..|||||::......|.|.|.||   |:...:..|:.|       ...:.|:..|.....:|
Zfish   620 RVLQTERGLLLRRAVRRDAGVYQCH---SMEHGFTQTILAITLEILPSAGSAPSAVNPRSPAHS- 680

  Fly   682 WCHEFEKYKTAMKSWEKKQAQCSTRQNFSSNQHPN 716
              |......|..|.|.:...|..        .|||
Zfish   681 --HVSHGQSTNQKLWYRDFMQLV--------DHPN 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Sema2a	NP_477507.1	Sema_2A	66..523	CDD:200499	156/493 (32%)
Sema2a	NP_477507.1	Ig_Semaphorin_C	573..664	CDD:143180	29/98 (30%)
sema3b	NP_001121818.1	Sema	46..515	CDD:301699	157/495 (32%)
		PSI	514..>550	CDD:214655	13/37 (35%)
		Ig_Semaphorin_classIII	574..664	CDD:143279	29/98 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9670
eggNOG	1	0.900	-	-		E1_KOG3611
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153798at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11036
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X596
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920